新疆地区PS基因多态性及血浆可溶性P选择素水平与心房颤动合并血栓栓塞的关联

发布时间：2018-01-16 17:22

本文关键词：新疆地区PS基因多态性及血浆可溶性P选择素水平与心房颤动合并血栓栓塞的关联　出处：《新疆医科大学》2015年硕士论文　论文类型：学位论文

【摘要】：目的：以中国新疆地区汉族、维吾尔族非瓣膜性心房颤动合并血栓栓塞患者及非瓣膜性心房颤动无血栓栓塞患者为研究对象,探讨目前已知的可能涉及心房颤动合并血栓栓塞形成的P选择素(P. selectin, PS)基因2123C/G位点和Thr715Pro位点多态性与心房颤动(房颤)血栓栓塞形成的相关性及其是否具有民族差异性。方法：对新疆地区302例维吾尔族心房颤动患者和340例与其年龄、性别比例相似的汉族心房颤动患者进行研究,采用ELISA方法测定其各自血浆中sPS浓度,并采用聚合酶链反应(PCR)和限制性片断长度多态性,探讨P选择素(P-selection,PS)基因在2123C/G位点、Thr715Pro位点多态性与心房颤动(房颤)血栓栓塞形成的相关性及汉族与维吾尔族之间是否具有民族差异性。结果：病例组(心房颤动合并血栓栓塞)血浆中sPS水平显著高于对照组(心房颤动无血栓栓塞)。病例组与对照组PS基因2123C/G位点基因型分布存在显著性差异,汉族与维吾尔族PS基因在2123C/G位点基因型分布不存在差异；汉族与维吾尔族的病例组与对照组PS基因在Thr715Pro位点基因型分布均无差异性。结论：血浆sPS水平和PS基因多态性与心房颤动合并血栓栓塞形成存在一定的关联,非瓣膜性心房颤动患者并发血栓形成可能存在遗传易感性。
[Abstract]:Objective: to study non-valvular atrial fibrillation with thromboembolism and non-valvular atrial fibrillation without thromboembolism in Chinese Han nationality and Uygur nationality. To investigate the known P-selectin P. selectin, which may involve atrial fibrillation with thromboembolism. Polymorphism of 2123C / r G and Thr715Pro loci in PSN gene and atrial fibrillation (AF). Methods: 302 Uygur patients with atrial fibrillation (Uygur) and 340 patients with Uygur atrial fibrillation (Uygur) were enrolled in this study. The study was carried out in patients with atrial fibrillation of Han nationality with similar sex ratio. The concentration of sPS in their respective plasma was determined by ELISA method. Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) were used. Objective: to investigate the P selectin P-selectiono PSN gene at 2123C / G locus. The association between polymorphism of Thr715Pro locus and thromboembolism of atrial fibrillation (AF) and whether there are ethnic differences between Han and Uygur. Results: case group (. Plasma sPS levels in patients with atrial fibrillation with thromboembolism were significantly higher than those in the control group (atrial fibrillation without thromboembolism). The genotype distribution of 2123C / G locus of PS gene was significantly different between the case group and the control group. There was no difference in the distribution of PS gene genotypes between Han and Uygur at 2123C / G locus. There was no difference in the distribution of PS gene genotypes between Han and Uygur patients in Thr715Pro locus. Plasma sPS levels and PS gene polymorphisms were associated with thromboembolism in patients with atrial fibrillation. There may be genetic susceptibility to thrombosis in patients with non-valvular atrial fibrillation.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R541.75

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