轻中度原发性高血压患者血管舒张功能与血清胱抑素C的关系

发布时间：2018-01-27 00:33

本文关键词： 原发性高血压内皮依赖性血管舒张功能血清胱抑素C　出处：《中华高血压杂志》2017年03期 　论文类型：期刊论文

【摘要】：目的探讨高血压患者血管舒张功能与血清胱抑素C的关系。方法选择2011年11月至2016年1月福建医科大学附属第一医院就诊的轻、中度原发性高血压患者471(男224、女247)例,年龄(59.8±13.0)岁。根据胱抑素C中位数(0.92mg/L)将高血压患者分为胱抑素C升高组(H-Cys)和胱抑素C正常组(N-Cys)。选择同期未服用任何药物在我院门诊初诊的非高血压者147例作为对照组。采用高分辨超声测定反应性充血前后胫前动脉内径的变化率为内皮依赖性舒张(EDD)功能,采用乳胶增强免疫透射比浊法测定血清胱抑素C。结果与对照和N-Cys组相比,H-Cys组患者的胱抑素C水平升高[(1.10±0.19)比(0.89±0.26),(0.77±0.11)mg/L,P0.05],EDD减退[(8.00±4.26)%比(9.42±5.58)%,(10.69±5.63)%,P0.05]。亚组分析发现,随着年龄的增长,高血压患者的EDD呈减弱趋势,胱抑素C水平呈升高趋势(均P0.05)。体质量指数(BMI)超重的高血压患者EDD较BMI正常的高血压患者EDD减退。胫前动脉EDD与胱抑素C、年龄、肌酐、尿酸呈负相关(r=-0.157、-0.292、-0.148、-0.186,均P0.05);多元线性回归分析显示,胱抑素C是高血压患者EDD的影响因素(B=-0.019,P0.05)。结论原发性高血压患者血清胱抑素C与血管舒张功能相关。
[Abstract]:Objective to investigate the relationship between vasodilation function and serum cystatin C in patients with hypertension. 471cases of moderate essential hypertension (224males and 247females). According to the median value of cystatin C (0.92 mg / L), hypertensive patients were divided into two groups: cystatin C elevated group and cystatin C normal group (P < 0.05). N-Cysn). 147 non-hypertensive patients who had not taken any drugs at the same time were selected as control group. The change rate of the internal diameter of anterior tibial artery before and after reactive hyperemia was determined by high-resolution ultrasound. Eddi) functionality. Serum cystatin C was determined by latex enhanced immunoturbidimetry. Results compared with the control group and N-Cys group, the level of cystatin C was increased. [1.10 卤0.19) vs 0.89 卤0.26 mg / L of 0.77 卤0.11 mg / L / L, P 0.05] decreased EDD. [Compared with 9.42 卤5.58%, 8.00 卤4.26% was 10.69 卤5.63% (P0.05). Subgroup analysis showed that it increased with age. The EDD of hypertensive patients tended to decrease. The level of cystatin C showed an increasing trend (all P0.05. BMIs). The EDD of overweight hypertensive patients was lower than that of BMI normal hypertensive patients. The EDD of anterior tibial artery and cystatin C. Age, creatinine and uric acid were negatively correlated with r-0.157- 0.292U -0.148U -0.186.All of them had a negative correlation (P 0.05). Multiple linear regression analysis showed that cystatin C was the influencing factor of EDD in patients with hypertension. Conclusion Serum cystatin C is correlated with vasodilation function in patients with essential hypertension.
【作者单位】：福建医科大学附属第一医院福建省高血压研究所;
【分类号】：R544.11
【正文快照】： 近年随着对高血压研究的不断深入,发现多个与靶器官损害有关的指标,胱抑素C也成为临床研究的关注热点之一。高血压与胱抑素C的关系复杂,胱抑素C既可作为反映肾小球滤过率变化的理想内源性标志物,也是评价肾功能损害的一项敏感指标[1-2],尤其是在血清肌酐仍在正常范围内时能早

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