生血灵系列制剂联合西药治疗激素抵抗型原发免疫性血小板减少症30例临床观察

发布时间：2018-01-30 06:58

本文关键词： 免疫性血小板减少症生血灵激素抵抗血小板计数　出处：《中医杂志》2017年06期 　论文类型：期刊论文

【摘要】：目的观察生血灵系列制剂治疗激素抵抗型原发免疫性血小板减少症(ITP)的临床疗效。方法将激素抵抗型ITP患者60例随机分为治疗组30例(给予生血灵系列辨证联合小剂量糖皮质激素治疗)和对照组30例(给予环孢素联合小剂量激素治疗)。两组均以3个月为1个疗程,治疗2个疗程后观察两组治疗前后血小板计数(PLT)、出血评分,并评价西医临床疗效、中医证候疗效及不良反应。结果两组治疗后较治疗前比较,PLT升高、中医证候积分及出血评分降低(P0.01),且治疗组治疗后PLT较对照组升高明显、中医证候积分降低明显(P0.01)。治疗组西医临床疗效总有效率80.0%,对照组总有效率43.3%,治疗组明显高于对照组(P0.01)。治疗组中医证候疗效总有效率86.67%,对照组为50.00%,治疗组优于对照组(P0.01)。结论生血灵系列制剂治疗激素抵抗型ITP疗效优于环孢素软胶囊,可明显改善患者的出血症状,与环孢素作用相似,而不良反应明显低于环孢素。
[Abstract]:Objective to observe the clinical efficacy of Shengxueling series preparations in the treatment of steroid-resistant primary immune thrombocytopenia. Methods 60 patients with steroid resistant ITP were randomly divided into treatment group (n = 30) and control group (n = 30). The patients were treated with Shengxueling series syndrome differentiation combined with low-dose glucocorticoid therapy and control group (30 cases were treated with cyclosporine combined with low-dose glucocorticoid). The two groups were treated with 3 months as a course of treatment. After two courses of treatment, the platelet count and PLT, bleeding score were observed before and after treatment, and the clinical efficacy of western medicine, TCM syndromes and adverse reactions were evaluated. Results the two groups were compared before and after treatment. PLT increased, TCM syndrome score and bleeding score decreased P0.01, and the treatment group after treatment PLT was significantly higher than the control group. The total effective rate of western medicine in the treatment group was 80.0 and the total effective rate in the control group was 43.3%. The total effective rate of TCM syndromes in the treatment group was 86.67 and that in the control group was 50.00%. Conclusion the treatment group is superior to the control group in the treatment of steroid-resistant ITP, which can significantly improve the bleeding symptoms of the patients, similar to the effect of cyclosporine. The adverse effects were significantly lower than that of cyclosporine.
【作者单位】：上海中医药大学附属岳阳中西医结合医院;上海中医药大学基础医学院;
【基金】：上海市科学技术委员会科研计划项目(14401970800) 上海中医药大学预算内项目(自然科学类)(2013JW48) 上海市杏林新星计划(ZY3-RCPY-2-2012)
【分类号】：R558.2
【正文快照】： 原发免疫性血小板减少症(idiopathic thrombo-cytopenic purpura,ITP)是一种获得性自身免疫性疾病,临床以皮肤黏膜出血为主,大多反复发作,缠绵难愈,严重者可有内脏甚至颅内出血导致死亡。长期以来,糖皮质激素一直是治疗本病的一线药物,但在多次足量或长期使用激素后,多数患者

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