高血压肾损害危险因素和炎性因子的临床分析

发布时间：2018-01-30 03:10

本文关键词： 原发性高血压慢性肾损害炎性因子　出处：《临床心血管病杂志》2017年08期 　论文类型：期刊论文

【摘要】：目的:探讨原发性高血压(essential hypertension,EH)患者血清炎性因子和临床相关生化指标及高危因素在慢性肾损害(chronic kidney damage,CKD)中的作用,分析其与EH患者发生CKD的关系。方法:选取符合纳入标准的EH患者127例,按照靶器官损伤(target organ damage,TOD)标准分为单纯EH组79例,EH合并CKD组48例。测定每组患者临床相关的生化指标和血管特异性炎性因子脂蛋白相关磷脂酶A2(lipoprotein associated phospholipase A2,LP-PLA2)水平,统计每组患者的相关危险因素,采用多因素logistic回归分析EH患者发生CKD的各因素及其临床意义。结果:超敏C反应蛋白(hypersensitive c-reactive protein,hs-CRP)、LP-PLA2、尿酸(uric acid,UA)是EH患者发生CKD的重要独立危险因素,其中UA是最重要的独立危险因素(OR:15.307,95%CI:4.022~58.250,P0.0001)。UA的标化偏回归系数b'绝对值最大(1.026),提示UA对EH患者发生CKD的影响最大。结论:UA、LP-PLA2、hs-CRP是EH发生CKD重要的独立危险因素,可能对CKD的预防和治疗提供新方向。
[Abstract]:Objective: To investigate the primary hypertension (essential, hypertension, EH) in serum of patients with inflammatory factors and clinical biochemical indicators and risk factors in chronic renal damage (chronic kidney damage, CKD) plays a role in the analysis of its relationship with EH in patients with CKD. Methods: 127 patients with EH in compliance with the standard. According to the target organ damage (target organ, damage, TOD) divided into simple EH group of 79 cases, 48 cases of EH combined with CKD group. Each group was measured in patients with clinically relevant biochemical indexes and blood vessel specific inflammatory factor of lipoprotein associated phospholipase A2 (lipoprotein associated phospholipase A2, LP-PLA2) level, the related risk factors of patients with each group of statistics and by using logistic regression analysis, the factors of EH CKD patients and its clinical significance. Results: high sensitivity C reactive protein (hypersensitive C-reactive, protein, hs-CRP, LP-PLA2), uric acid (uric acid, UA EH) An important independent risk factor for the incidence of CKD in patients with UA, which is the most important independent risk factors (OR:15.307,95%CI:4.022~58.250, P0.0001).UA standardized partial regression coefficient B'of the maximum absolute value (1.026), suggesting that UA has the greatest impact on EH in patients with CKD. Conclusion: UA, LP-PLA2, hs-CRP is one of the important independent risk factors of CKD EH, may provide a new direction for prevention and treatment of CKD.

【作者单位】：山西省人民医院心内科;
【基金】：山西省社会发展基金(No:20120313018-8)
【分类号】：R544.11;R692
【正文快照】： 原发性高血压(essential　hypertension,EH)导致心、脑、肾和血管等靶器官损伤(target　organdamage,TOD)是复杂的生化、炎症和血流动力学等机制参与的病理过程。有研究证据显示动脉粥样硬化(atherosclerosis,AS)是EH导致不同TOD发生的主要机制,炎症学说又被认为是AS发生的

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