原发性血小板增多症患者的预后和生存分析

发布时间：2018-01-30 00:09

  本文关键词： 原发性血小板增多症 预后因素 生存分析　出处：《中国实验血液学杂志》2017年02期 　论文类型：期刊论文

【摘要】：目的:探讨原发性血小板增多症(ET)患者的预后及生存状态,分析影响该疾病生存的预后因素,为临床诊治和判定预后提供依据。方法:对2002年12月至2013年12月在中山大学附属第五医院和中山市人民医院住院确诊的ET患者进行统计分析,总结其临床特点并进行生存曲线分析及多因素分析,寻找该疾病的生存特点及影响预后的危险因素。结果:118例ET患者的生存情况为1年生存率95.5%,3年生存率92.6%,5年生存率89%,10年生存率81.6%。Kaplan-Meier法生存分析提示年龄≥60岁、有心血管危险因素、既往有血栓或出血病史、贫血(血红蛋白120 g/L)、血小板计数升高(≥1 000×109/L)、疾病危险分级、高危组中使用羟基脲或/和高三尖杉酯碱对生存率的影响有统计学意义(P0.05)。COX回归分析显示,未发现影响生存率的独立危险因素。结论:ET患者的生存率高,生存时间长,转化为骨髓纤维化和白血病的风险低,年龄≥60岁、有心血管疾病危险因素、既往有血栓或出血病史、贫血、血小板计数升高是影响预后的危险因素,在高危组中使用羟基脲或/和高三尖杉酯碱能改善预后
[Abstract]:Objective: to investigate the prognosis and survival status of patients with idiopathic thrombocytopenia (et) and to analyze the prognostic factors affecting the survival of the disease. Methods: to provide evidence for clinical diagnosis, treatment and prognosis. From December 2002 to December 2013, the et patients who were hospitalized in 5th affiliated Hospital of Sun Yat-sen University and Zhongshan people's Hospital were statistically analyzed. The clinical characteristics were summarized and survival curve analysis and multivariate analysis were carried out. Results the survival rate of one year survival rate was 95.50.The 3-year survival rate was 92.6 and the 5-year survival rate was 89%. The survival rate of 10 years was 81.6%. Kaplan-Meier survival analysis showed that the age 鈮，

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