阿托伐他汀的不同用药方式对心肌缺血再灌注损伤的影响及机制

发布时间：2018-01-30 18:42

本文关键词： 阿托伐他汀心肌缺血/再灌注 ATP酶大鼠白细胞介素-(IL-) 肿瘤坏死因子-α(TNF-α) 心肌梗死　出处：《西安交通大学学报(医学版)》2017年03期 　论文类型：期刊论文

【摘要】：目的探讨阿托伐他汀的不同用药方式对心肌缺血/再灌注(myocardial ischemia/reperfusion,MI/R)损伤的影响及机制。方法建立SD大鼠在体MI/R模型。160只大鼠随机分为MI/R组、MI/R+阿托伐他汀常规剂量(MI/R+N)组、MI/R+术前单次负荷剂量(MI/R+SL)组、MI/R+术前连续负荷剂量(MI/R+ML)组,并设假手术(Sham)组。Evans blue/TTC双染色测定心肌梗死面积;检测心肌ATP酶活性及血清白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)水平;小动物超声测定左室射血分数(LVEF%)。结果与MI/R+N组比较,MI/R+SL组和MI/R+ML组的心肌梗死面积明显减少(P0.05),心肌ATP酶活性明显增高(P0.05),血清IL-6和TNF-α水平明显减低(P0.05),MI/R后24hLVEF%显著改善(P0.05)。而MI/R+SL组和MI/R+ML组间的心肌梗死面积、心肌ATP酶活性、IL-6和TNF-α水平、LVEF%的差异无统计学意义。结论负荷剂量阿托伐他汀可通过改善心肌ATP代谢,减少炎症因子异常表达等机制,减轻MI/R损伤。术前单次负荷剂量与术前连续负荷剂量的用药方式对保护MI/R无差别。
[Abstract]:Objective to investigate the effects of different drug methods of Atto vastatin on myocardial ischemia / reperfusion myocardial ischemia/reperfusion. Methods the MI/R model of SD rats in vivo was established. 160 rats were randomly divided into MI/R group. The routine dose of MI/R Atto vastatin was given to the MIP / R group, and the single load dose before MIR / R was given to the MIP / R group. The area of myocardial infarction was determined by continuous load dose before MI/R and sham group. Evans blue/TTC double staining was used to measure myocardial infarction area. Myocardial ATP enzyme activity, serum interleukin-6 (IL-6) and tumor necrosis factor- 伪 (TNF- 伪) were measured. Left ventricular ejection fraction (LVEF) was measured by ultrasound in small animals. Results compared with MI/R N group, myocardial infarction size in MIP / R SL group and MI/R ML group was significantly reduced (P 0.05). The activity of ATP in myocardium increased significantly (P 0.05), and the levels of serum IL-6 and TNF- 伪 decreased significantly (P 0.05). 24 h after MI/R, LVEF% significantly improved the myocardial infarct size and myocardial ATP enzyme activity between MI/R SL group and MI/R ML group. There was no significant difference between IL-6 and TNF- 伪 levels in LVEF%. Conclusion Atto vastatin can improve myocardial ATP metabolism and reduce the abnormal expression of inflammatory factors. There was no difference between preoperative single load dose and preoperative continuous load dose in protecting MI/R.
【作者单位】：西安交通大学第一附属医院心内科;陕西省中医医院;陕西省核工业二一五医院;
【基金】：国家自然科学基金项目资助(No.81370357;No.81570381)~~
【分类号】：R542.2
【正文快照】： 缺血/再灌注(myocardial ischemia/reperfusion,MI/R)损伤是经皮冠状动脉介入治疗(PCI)缺血性心肌病时常见的心肌代谢功能障碍,也是随着PCI广泛开展而亟需解决的重点问题[1-2]。作为新一代他汀类药物,阿托伐他汀的抗炎性、抗细胞凋亡、免疫调节作用等多重药理效应使其在MI/R损

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