非编码核糖核酸在心房颤动中的研究现状

发布时间：2018-02-01 02:10

本文关键词： 心房颤动微小核糖核酸长链非编码核糖核酸表达谱分子机制　出处：《中国临床药理学杂志》2017年11期 　论文类型：期刊论文

【摘要】：心房颤动是临床发病率最高的心律失常,可诱发心力衰竭、卒中及外周血管栓塞等致死性心脑血管疾病。随着全球人口老龄化加剧,心房颤动患者逐年增加,造成巨大的社会和经济负担。目前,药物是心房颤动临床治疗的主要手段,然而药物治疗的有效率低,并存在致心律失常的风险。近年来,非编码核糖核酸(RNAs)在个体发育及多种疾病的发生发展中的重要作用日益显现。越来越多研究表明,非编码RNAs与心房颤动的发生和维持密切相关。阐明非编码RNAs在心房颤动中的作用及调控机制,建立心房颤动相关非编码RNAs交互网络,对临床早期预测患者心房颤动易感性,发现新的药物治疗靶点及评估患者预后情况具有重要意义。本文综述非编码RNAs在心房颤动研究中的新进展。
[Abstract]:Atrial fibrillation (AF) is the most common arrhythmia, which can induce fatal cardiovascular and cerebrovascular diseases such as heart failure, stroke and peripheral vascular embolism. With the aggravation of the global population, the number of patients with atrial fibrillation increases year by year. At present, drugs are the main method of clinical treatment for atrial fibrillation. However, the effective rate of drug therapy is low, and there is a risk of arrhythmia in recent years. Noncoding RNAss play an increasingly important role in ontogeny and the occurrence and development of many diseases. Non-coding RNAs was closely related to the occurrence and maintenance of atrial fibrillation. The role and regulatory mechanism of non-coded RNAs in atrial fibrillation were clarified and the non-coding RNAs interactive network of atrial fibrillation was established. It is of great significance to predict the susceptibility of patients to atrial fibrillation, to find new therapeutic targets and to evaluate the prognosis of patients with atrial fibrillation. This paper reviews the recent progress of non-coding RNAs in the study of atrial fibrillation.
【作者单位】：哈尔滨医科大学药理教研室;
【基金】：国家自然科学基金资助项目(81673426)
【分类号】：R541.75
【正文快照】： 非编码核糖核酸(ncRNAs)与心房颤动的发生和维持密切相关[1-2]。阐明非编码RNAs在心房颤动中的作用及调控机制,建立心房颤动相关非编码RNAs交互网络,对临床早期预测患者的心房颤动易感性,发现新的药物治疗靶点及评估患者预后情况具有重要意义。本文主要就微小RNAs(miRNAs)和长

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