骨桥蛋白与高敏C反应蛋白对冠状动脉介入治疗后再狭窄的预测价值

发布时间：2018-02-02 21:04

本文关键词： 骨桥蛋白高敏C反应蛋白冠状动脉介入治疗冠状动脉支架内再狭窄　出处：《医学与哲学(B)》2017年01期 　论文类型：期刊论文

【摘要】：探讨血浆高敏C反应蛋白(hs-CRP)及骨桥蛋白(OPN)对冠状动脉介入治疗(PCI)后患者冠状动脉支架内再狭窄(ISR)发生的预测价值,并比较二者对ISR预测的准确性。收集2014年5月~2015年5月于笔者所在医院成功施行PCI并自愿随访冠状动脉造影(CAG)的患者206例,术后随访1年,根据复查CAG的结果将入选者分为再狭窄组(n=28)和无再狭窄组(n=178),复查CAG时检测两组患者血浆hs-CRP、OPN等生化指标,进行统计分析。再狭窄组患者hs-CRP及OPN水平均高于无再狭窄组,Logistic分析结果显示hs-CRP及OPN水平对PCI后发生ISR有独立的预测价值,当hs-CRP及OPN取最佳临界值时OPN对IRS诊断的特异性、准确性及阳性预测值均高于hs-CRP。相对于hs-CRP,OPN对PCI后发生ISR具有更好的预测价值,尤其是其诊断的特异性、准确性及阳性预测值更具优势,值得推广。
[Abstract]:To investigate the predictive value of plasma Gao Min C-reactive protein hs-CRP and osteopontin (OPN) in coronary artery restenosis (ISR) after coronary intervention (PCI). From May 2014 to May 2015, PCI was successfully performed in our hospital and coronary arteriography was followed up voluntarily. There were 206 cases. The patients were divided into restenosis group (n = 28) and non-restenosis group (n = 178) according to the results of CAG. The plasma hs-CRP was measured when CAG was reexamined. The levels of hs-CRP and OPN in restenosis group were higher than those in non-restenosis group. The results of Logistic analysis showed that the levels of hs-CRP and OPN had independent predictive value for the occurrence of ISR after PCI. The specificity, accuracy and positive predictive value of OPN in the diagnosis of IRS were higher than those of hs-CRP. relative to hs-CRP when hs-CRP and OPN obtained the best critical value. OPN has a better predictive value for the occurrence of ISR after PCI, especially for its specificity, accuracy and positive predictive value, which is worth popularizing.
【作者单位】：锦州医科大学附属第一医院心内科;锦州市中心医院心内科;
【基金】：2016年辽宁省自然科学基金项目(201602300)
【分类号】：R541.4
【正文快照】： 冠状动脉介入治疗(percutaneous coronary inter-vention,PCI)是治疗冠心病的最有效手段之一,大大降低了急性心肌梗死患者的病死率,提高了患者的生活质量,但术后冠状动脉支架内再狭窄(in-stent restenosis,ISR)的发生严重影响了PCI的疗效及患者的预后[1]。如何及早识别ISR的发

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