左卡尼汀对老年急性冠脉综合征患者血清心衰标志物及炎症因子水平的影响

发布时间：2018-02-03 15:44

本文关键词： 急性冠脉综合征左卡尼汀血清炎性因子心衰标志物糖类抗原　出处：《山东医药》2017年33期 　论文类型：期刊论文

【摘要】：目的探讨左卡尼汀对老年急性冠脉综合征(ACS)患者血清心衰标志物及炎症因子水平的影响。方法选取ACS患者120例,随机分为对照组和观察组,每组各60例;对照组患者接受硝酸酯类、肠溶阿司匹林及氯吡格雷等药物进行常规治疗,观察组在常规治疗的基础上加用左卡尼汀注射液,两组患者均持续治疗2周。检测两组患者治疗前后血清糖类抗原125(CA125)、N末端脑钠尿肽前体(NT-pro BNP)和脑钠尿肽(BNP)水平,超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)、胱抑素C(Cystatin C)水平,并记录两组患者不良反应发生情况。结果两组患者治疗后血清CA125、NT-pro BNP、BNP、hs-CRP、IL-6、IL-8和TNF-α水平均较治疗前降低(P均0.05),Cystatin C水平较治疗前增高(P0.05);治疗后比较,观察组以上检测指标差异均有统计学意义(P均0.05)。两组患者胃肠道不适、过敏性皮炎等不良反应的发生率差异无统计学意义(P均0.05)。结论左卡尼汀能明显降低ACS患者血清心衰标志物及炎症因子水平,增强心功能,且安全性良好。
[Abstract]:Objective to investigate the effects of levacarnitine on serum markers of heart failure and inflammatory factors in elderly patients with acute coronary syndrome (ACS). Methods 120 patients with ACS were randomly divided into two groups: control group and observation group. 60 cases in each group; The patients in the control group received routine treatment with nitrate, enteric aspirin and clopidogrel, and the observation group was treated with L-carnitine injection on the basis of routine treatment. The patients in both groups were treated continuously for 2 weeks. The serum carbohydrate antigen 125 (CA125) was detected before and after treatment in both groups. N-terminal brain natriuretic peptide (NT-pro BNPs) and brain natriuretic peptide (BNPs) levels, hypersensitive C-reactive protein (hs-CRP), interleukin-6 (IL-6). Interleukin-8 (IL-8), tumor necrosis factor- 伪 (TNF- 伪), cystatin Cystatin (Cystatin C). Results after treatment, serum CA125 NT-pro BNPP BNPHs-CRPU IL-6 were recorded. The levels of IL-8 and TNF- 伪 were lower than those before treatment. After treatment, the difference of the above indexes in the observation group was statistically significant (P < 0.05). The patients in the two groups were ill with gastrointestinal tract. There was no significant difference in the incidence of adverse reactions such as allergic dermatitis (P < 0.05). Conclusion Levocarnitine can significantly reduce the serum markers of heart failure and inflammatory factors in patients with ACS and enhance cardiac function. And the safety is good.
【作者单位】：承德市中心医院;围场县医院;
【基金】：河北省医学科学研究重点课题(ZD20140455) 承德市科学技术研究与发展项目(201601A014)
【分类号】：R541.4
【正文快照】： 急性冠脉综合征(ACS)是指冠状动脉粥样斑块破裂与血栓形成引发的严重心肌缺血事件,主要包括不稳定型心绞痛和急性心肌梗死[1],动脉粥样硬化斑块不稳定以及炎症反应在其发生发展中也发挥了重要作用[2]。临床研究显示左卡尼汀能够有效地改善慢性心功能不全患者的心肌营养代谢,增

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