同种和不同种药物洗脱支架治疗冠状动脉药物洗脱支架内再狭窄有效性的系统评价

发布时间：2018-02-25 01:29

本文关键词： 冠状动脉再狭窄药物洗脱支架　出处：《中国动脉硬化杂志》2017年01期 　论文类型：期刊论文

【摘要】：目的评价同种药物洗脱支架和不同种药物洗脱支架治疗冠状动脉药物洗脱支架内再狭窄的有效性。方法计算机检索Pub Med、OVID、Embase、Cochrane图书馆、万方数据库、中国学术期刊全文数据库(CNKI)、中国生物医学文献数据库(CBM)、维普数据库(VIP),收集同种和不同种药物洗脱支架治疗冠状动脉药物洗脱支架内再狭窄的临床资料,共纳入10项研究,1680名患者,使用Rev Man5.2软件进行系统评价。检索时间为各大数据库建库至2015年10月。结果在治疗冠状动脉药物洗脱支架内再狭窄时,采用不同药物洗脱支架可降低靶病变血运重建率(OR=0.73,95%CI为0.55~0.96,P=0.02)和主要不良心血管事件发生率(OR=0.72,95%CI为0.54~0.96,P=0.03)。两组间的病死率(OR=1.03,95%CI为0.49~2.16,P=0.95)和心肌梗死发生率(OR=0.59,95%CI为0.24~1.41,P=0.23)无统计学差异。结论对于药物洗脱支架内再狭窄患者,再次植入不同药物洗脱支架比植入同种支架更获益。
[Abstract]:Objective to evaluate the efficacy of drug-eluting stents and drug-eluting stents in the treatment of restenosis in drug-eluting coronary stents. CNKI database of Chinese academic journals, CBMN of Chinese biomedical literature database, VIPP database of Weip, collected clinical data of the same and different drug eluting stents for the treatment of restenosis in drug-eluting stents of coronary artery. A total of 1 680 patients were included in 10 studies and evaluated systematically by using Rev Man5.2 software. The retrieval time was built up to October 2015. Results in the treatment of restenosis in drug-eluting coronary stents, Using different drug-eluting stents could decrease the rate of revascularization of target lesions and the incidence of major adverse cardiovascular events (OR 0.7395 CI was 0.550.96 P0.02) and the incidence of major adverse cardiovascular events was 0.540.96% P0.03.Conclusion there was no significant difference in mortality rate between the two groups (OR1.0395CI = 0.492.16P0.95) and the incidence of myocardial infarction (Ori 0.5995CI = 0.2441P 0.23C). For patients with restenosis in drug-eluting stents, Reimplantation of different drug-eluting stents is more beneficial than implantation of the same stent.
【作者单位】：新疆喀什地区第一人民医院心内二科;
【分类号】：R543.3

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