参芪地黄汤加减联合西药治疗高血压肾病临床研究

发布时间：2018-02-25 02:11

本文关键词： 参芪地黄汤硝苯地平卡托普利高血压肾病　出处：《辽宁中医杂志》2017年08期 　论文类型：期刊论文

【摘要】：目的:探讨参芪地黄汤加减联合西药治疗高血压肾病的疗效。方法:根据随机数字表法将2012年1月—2016年7月本院收治的180例高血压肾病患者分为对照组(90例)与观察组(90例),对照组患者接受硝苯地平联合卡托普利治疗,观察组患者在硝苯地平、卡托普利基础上再联合使用参芪地黄汤,现对比分析两组患者的治疗效果。结果:(1)组内不同时间点之间的血压比较:治疗前、治疗1个月后、治疗3个月后,观察组与对照组3个时间点之间的舒张压(DBP)、收缩压(SBP)比较差异均有统计学意义(P0.05),治疗前的DBP、SBP均显著高于治疗1个月后、治疗3个月后(P0.05),治疗1个月后的DBP、SBP均显著高于治疗3个月后(P0.05)。(2)组内不同时间点之间的肾功能指标比较:治疗前、治疗1个月后、治疗3个月后,观察组与对照组3个时间点之间的血清胱抑素C(SCys C)、估算肾小球滤过率(eGFR)、尿微量白蛋白(Um Alb)相比差异均有统计学意义(P0.05);治疗前的SCys C、Um Alb显著高于治疗1个月后、治疗3个月后(P0.05),eGFR显著低于治疗1个月后、治疗3个月后(P0.05);治疗1个月后的SCys C、Um Alb显著高于治疗3个月后(P0.05),eGFR显著低于治疗3个月后(P0.05)。不同时间点两组之间肾功能指标比较:治疗前,两组患者SCys C、eGFR、Um Alb相比差异均无统计学意义(P0.05);治疗1个月后、治疗3个月后,观察组SCys C、Um Alb显著低于对照组,eGFR均显著高于对照组,差异均有统计学意义(P0.05)。结论:参芪地黄汤加减联合西药治疗高血压肾病的疗效确切,在控制血压的同时有效保护患者肾功能,值得临床推广应用。
[Abstract]:Objective: to investigate the efficacy of Shenqi Dihuang decoction combined with western medicine in the treatment of hypertensive nephropathy. Methods: according to random number table, 180 patients with hypertension nephropathy admitted in our hospital from January 2012 to July 2016 were divided into control group (n = 90) and control group (n = 90). 90 patients in the observation group were treated with nifedipine combined with captopril, while the patients in the control group were treated with nifedipine and captopril. The patients in the observation group were treated with Shenqi Dihuang decoction on the basis of nifedipine and captopril. After 3 months of treatment, there were significant differences in DBP, SBP and SBP between the observation group and the control group at three time points. The SBP before treatment was significantly higher than that after 1 month treatment. After 3 months of treatment and 1 month after treatment, the levels of SBP in DBP group were significantly higher than those in the control group at different time points: before treatment, 1 month after treatment, and 3 months after treatment, there were significant differences in renal function index between the two groups after 3 months of treatment, 1 month after treatment, 3 months after treatment, 1 month after treatment, 3 months after treatment, 3 months after treatment, 3 months after treatment, 3 months after treatment. Compared with the control group, the serum cystatin cystatin (Cnscys), estimated glomerular filtration rate (GFR) and urinary microalbumin (Um Alb) in the observation group were significantly higher than those in the control group (P 0.05), and the SCys Con Um Alb before treatment was significantly higher than that after 1 month treatment. After 3 months of treatment, P0.05 eGFR was significantly lower than that after 1 month treatment. After 3 months of treatment, the levels of SCys Con Um Alb were significantly higher than those after 3 months of treatment. The renal function indexes of the two groups at different time points were significantly lower than those after 3 months of treatment. There was no significant difference in SCys CfR Um Alb between the two groups, but after one month of treatment and 3 months of treatment, the SCys CU Um Alb in the observation group was significantly lower than that in the control group, which was significantly higher than that in the control group. Conclusion: Shenqi Dihuang decoction combined with western medicine is effective in the treatment of hypertensive nephropathy, which can effectively protect renal function while controlling blood pressure, and is worth popularizing in clinic.
【作者单位】：华中科技大学同济医学院附属武汉中心医院中医科;
【分类号】：R544.1;R692

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