复杂冠脉病变介入术后应用那曲肝素抗凝对患者预后的影响

发布时间：2018-03-02 21:25

本文选题：冠状动脉　切入点：介入　出处：《广东医学》2017年08期 　论文类型：期刊论文

【摘要】：目的探讨复杂冠脉病变介入术后使用那曲肝素抗凝对患者预后的影响。方法选择接受经皮冠脉介入治疗的复杂冠脉病变患者为观察对象。根据患者术后是否使用那曲肝素分为非抗凝组和抗凝组,每组各50例患者。比较两组患者经介入治疗前后心肌损伤标志物变化、3个月内心血管事件发生情况和生活质量。结果两组患者介入治疗前心肌肌钙蛋白T(cTnT)和心肌肌酸激酶同工酶(CK-MB)水平无明显差别,介入治疗后24 h内,两组患者的上述指标均较手术前有所升高,且非抗凝组升高较抗凝组更明显(P0.05);两组患者介入治疗后3个月内急性心肌梗死发生率和出血发生率无明显差别,而抗凝组侧支闭塞率和病死率明显低于非抗凝组(P0.05);两组患者介入治疗后总体生活质量差异无统计学意义(P0.05)。结论复杂冠脉病变经介入治疗术后使用那曲肝素抗凝可明显降低侧支闭塞和病死率,具有较好的临床应用价值。
[Abstract]:Objective to investigate the effect of Natrix heparin anticoagulant therapy on the prognosis of patients with complicated coronary artery disease after coronary intervention. Methods patients with complicated coronary artery disease undergoing percutaneous coronary intervention were selected as observation objects. Naqu heparin was divided into non-anticoagulant group and anticoagulant group. The changes of myocardial injury markers, the occurrence of cardiovascular events and the quality of life in three months before and after interventional therapy were compared. Results before and after interventional therapy, cardiac troponin TnTnT) and myocardial muscle were compared between the two groups. There was no significant difference in creatine kinase isoenzyme CK-MBs. Within 24 hours after interventional therapy, the above indexes in both groups were higher than those before operation, and the increase in non-anticoagulant group was more obvious than that in anticoagulant group (P 0.05), and there was no significant difference in the incidence of acute myocardial infarction and bleeding within 3 months after interventional therapy between the two groups. However, the rate of collateral occlusion and mortality in the anticoagulant group were significantly lower than those in the non-anticoagulant group (P 0.05), and there was no significant difference in the overall quality of life between the two groups after interventional therapy. Conclusion after interventional treatment of complex coronary artery disease, Natrix heparin can be used as anticoagulant agent. The side branch occlusion and mortality were significantly reduced. It has good clinical application value.
【作者单位】：潮州市中心医院心血管内科;
【分类号】：R541.4

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