高敏肌钙蛋白T在老年慢性心力衰竭与急性心肌梗死鉴别诊断中的价值

发布时间：2018-03-02 18:38

  本文选题：高敏肌钙蛋白T　切入点：慢性心力衰竭　出处：《中国老年学杂志》2017年05期 　论文类型：期刊论文

【摘要】：目的研究老年患者高敏肌钙蛋白(hs-cTn)T升高程度在慢性心力衰竭(CHF)与急性心肌梗死(AMI)鉴别诊断中的价值。方法372例老年CHF患者作为CHF组296例老年AMI患者作为AMI组,并以238例健康老年体检人群为对照组,比较三组hs-cTnT水平。受试者工作特征(ROC)曲线分析hs-cTnT对CHF的诊断切点。结果 hs-cTnT在AMI组(3.245±1.356)ng/ml、CHF组(0.298±0.124)ng/ml及对照组(0.009±0.003)ng/ml的血浆浓度依次显著降低(P0.05);ROC曲线评价hs-cTnT对CHF的诊断价值,曲线下面积(AUC)为0.746(95%CI:0.696~0.864).诊断范围为0.09~2.38ng/ml;对AMI的诊断价值,AUC为0.865(95%CI:0.715~0.965),诊断切点为2.38ng/ml;不同美国纽约心脏病学会(NYHA)心功能CHF患者及对照组hs-cTnT比较,Ⅳ级(0.369±0.117)ng/ml、Ⅲ级(0.267±0.102)ng/ml、Ⅱ级(0.142±0.084)ng/ml及对照组(0.009±0.003)ng/ml血浆浓度依次降低,hs-cTnT与NYHA心功能经Pearson等级相关分析呈正相关(r=0.825,P0.05)。结论hs-cTnT作为心肌损伤特异性标志物在CHF及AMI的早期鉴别及CHF病情评估有重要应用价值。
[Abstract]:Objective to study the value of the elevation of troponin cTnTnTnTc in the elderly patients with chronic heart failure (CHF) and acute myocardial infarction (AMI). Methods 372 elderly patients with CHF were treated as CHF group, 296 elderly AMI patients as AMI group. 238 healthy elderly people were taken as control group. The diagnostic point of hs-cTnT for CHF was analyzed by comparing the three groups of hs-cTnT levels. Results the plasma concentrations of hs-cTnT in AMI group (3.245 卤1.356g / ml) and control group (0.298 卤0.124ng / ml) and control group (0.009 卤0.003ng / ml) were significantly lower than those in control group (P 0.05ng / ml) to evaluate the value of hs-cTnT in the diagnosis of CHF. Under the curve, the area under the curve is 0.746 / 95 CI: 0.696 / 0.864. The diagnostic range is 0.09 / 2.38 ng / ml; the diagnostic value for AMI is 0.865 95% CI: 0.715 / 0.965g / ml, and the diagnostic cutoff point is 2.38 ng / ml; the hs-cTnT of CHF patients and control group is different from that of the American New York Cardiac Association (NYHA). The plasma concentrations of grade 鈪，

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