血液肿瘤患者合并细菌感染时中性粒细胞CD64的变化

发布时间：2018-03-09 07:46

本文选题：血液肿瘤　切入点：细菌感染　出处：《中国实验血液学杂志》2017年02期 　论文类型：期刊论文

【摘要】：目的:探究血液肿瘤患者合并细菌感染时中性粒细胞表面CD64的变化。方法:选择2014年8月至2016年2月在我院就诊收治的血液肿瘤患者97例,作为此次临床研究的对象。根据患者的症状和体征以及微生物血培养检测结果,将患者分成血液肿瘤感染组(50例)和血液肿瘤非感染组(47例)。采用流式细胞术检测患者中性粒细胞表面CD64指数、血清C-反应蛋白(CRP)、中性粒细胞计数(NC)和降钙素原(PCT)水平。感染组患者接受治疗后,再次检测CD64、CRP、PCT以及NC水平。结果:未接受治疗时,感染组患者CD64指数明显高于非感染组,CRP、PCT和NC水平也高于非感染组;对感染组进行针对性的抗细菌感染治疗后,感染组CD64指数、CRP、PCT和NC水平均有所下降。结论:血液肿瘤患者合并细菌感染时CD64指数明显升高,治疗后有所降低,此结果肯定了CD64在诊断血液肿瘤患者细菌感染方面的价值
[Abstract]:Objective: To observe the changes of neutrophil surface CD64 on bacterial infection in patients with hematological tumor. Methods: from August 2014 to February 2016 in 97 patients with hematological malignancies in our hospital treated cases, as the object of this clinical study. According to the patient's symptoms and signs and microorganisms in blood culture test results, the patients were divided into infection group blood tumor (50 cases) and non tumor blood infection group (47 cases). Patients were detected by neutrophil CD64 index, flow cytometry, serum C- reactive protein (CRP), neutrophil count (NC) and procalcitonin (PCT) level. The infection group patients after treatment, detected again CD64 CRP, PCT, and NC level. Results: untreated, infected patients CD64 index was significantly higher than non infected group, CRP, PCT and NC levels were also higher than those of the control group; the infection group targeted against bacterial infection after treatment, CD64 infection group Index, CRP, PCT and NC levels all decreased. Conclusion: CD64 index of blood tumor patients with bacterial infection increased significantly, and decreased after treatment. This result confirms the value of CD64 in the diagnosis of bacterial infection in patients with hematological malignancies.

【作者单位】：青海省人民医院血液风湿科;
【基金】：国家临床重点专科建设项目(卫办医政函[2011]873号) 青海省人才小高地项目(青人才字[2014]12号)
【分类号】：R733

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