2型糖尿病合并不同分级高血压患者血清Giα-2、NGAL水平变化及意义

发布时间：2018-03-10 11:34

本文选题：型糖尿病　切入点：高血压　出处：《山东医药》2017年33期 　论文类型：期刊论文

【摘要】：目的探讨血清抑制性G蛋白α亚基-2(Giα-2)和中性粒细胞明胶酶相关脂质运载蛋白(NGAL)水平在2型糖尿病合并不同分级高血压患者中的改变及临床意义。方法选取197例2型糖尿病患者,分为单纯2型糖尿病(DS组)45例、2型糖尿病合并高血压1级(DH1组)47例、2型糖尿病合并高血压2级(DH2组)51例、2型糖尿病合并高血压3级(DH3组)54例;另选取40例查体无糖尿病和高血压者作为对照组。应用酶联免疫吸附法测定各组血清Giα-2和NGAL水平。多元线性回归法分析Giα-2和NGAL的影响因素。结果 DS组Giα-2水平较对照组降低,DH1、DH2、DH3组Giα-2水平均高于DS组,其中DH3组最高(P均0.05);DS组NGAL水平较对照组升高,在DH1、DH2、DH3组中,随着高血压分级增加,NGAL水平逐渐增加(P均0.05)。多元线性回归分析结果显示:Giα-2与收缩压呈正相关(r=0.54,P0.05),NGAL水平与收缩压、空腹血糖呈正相关(r=0.55、0.14,P均0.05)。进一步多元回归分析提示收缩压是血清Giα-2水平的独立影响因素,收缩压、空腹血糖是血清NGAL水平的独立影响因素。结论 2型糖尿病合并高血压患者血清Giα-2和NGAL水平均升高,Giα-2和NGAL水平变化对2型糖尿病合并高血压的发生均有一定影响。
[Abstract]:Objective to investigate the changes and clinical significance of serum inhibitory G protein 伪 subunit (Gi 伪 -2) and neutrophil gelatinase-associated lipid carrier protein (NGALs) levels in patients with type 2 diabetes mellitus complicated with hypertension of different grades. Methods 197 patients with type 2 diabetes mellitus were selected. The patients were divided into 45 patients with type 2 diabetes mellitus complicated with hypertension grade 1 DH1 and 47 patients with type 2 diabetes mellitus with hypertension grade 2 DH2 group with 51 patients with type 2 diabetes mellitus complicated with hypertension grade 3 DH3 group (n = 54). The serum levels of GI 伪 -2 and NGAL were determined by enzyme linked immunosorbent assay (Elisa). The influencing factors of GI 伪 2 and NGAL were analyzed by multivariate linear regression method. Results the levels of GI 伪 -2 in DS group were higher than those in DS group. The levels of GI 伪 -2 in the control group were significantly higher than those in the DS group. The NGAL level in the DH3 group was higher than that in the control group (P < 0.05). In the DH1 / DH2 / DH3 group, the NGAL level increased gradually with the increase of the grade of hypertension (P < 0.05). The results of multiple linear regression analysis showed that there was a positive correlation between the systolic blood pressure (SBP) and the level of NGAL in the DH3 group (0.54P0.05NGAL), and there was a positive correlation between the NGAL level and the systolic blood pressure (SBP) in the DH1 / DH2DH3 group. There was a positive correlation between fasting blood glucose (FBG) and serum Gi 伪 -2 levels. The results showed that systolic blood pressure (SBP) was an independent factor of serum GI 伪 -2 level, and systolic blood pressure (SBP). Conclusion the changes of serum GI 伪 -2 and NGAL levels in patients with type 2 diabetes mellitus complicated with hypertension have some influence on the occurrence of type 2 diabetes mellitus with hypertension.
【作者单位】：承德医学院;保定市第一中心医院;
【基金】：国家自然科学基金项目(81500644) 河北省医学科学研究重点课题计划(20160282)
【分类号】：R544.1;R587.1

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