男性骨密度与冠状动脉粥样硬化关系的Meta分析

发布时间：2018-03-12 12:19

本文选题：骨密度　切入点：冠状动脉粥样硬化　出处：《中国骨质疏松杂志》2017年08期 　论文类型：期刊论文

【摘要】：目的从循证医学的角度探究男性骨密度改变与冠状动脉粥样硬化之间的关系。方法首先根据研究的目的制定检索策略,利用Pubmed、Embase、Cochrane图书馆、中国生物医学文献数据库(CBM)、维普信息资源系统、相关期刊论文(CNKI)、万方数据库等检索截至目前已发表的相关文献,对符合纳入标准的文献进行数据的提取,利用Review Manager 5.3Meta分析软件对提取的数据进行分析。结果本研究最终纳入5篇文献,包含骨密度降低组(骨量减少和骨质疏松)325名患者,对照组259名患者。Meta分析显示5项研究之间的异质性检验结果为I~2=62%,Chi~2=10.56,P=0.03,说明各研究之间存有异质性,因此采用随机效应模型进行分析,合并后的效应量为OR=1.79,95%CI为(0.79,4.03),P=0.16;经灵敏度分析剔除1篇样本量较小的研究后,异质性检验结果显示I~2=35%,Chi~2=4.64,P=0.20,表明各研究之间的异质性较小并且可以接受,因此采用固定效应模型进行分析,合并后的效应量为OR=1.22,95%CI为(0.76,1.96),P=0.41,最后所得的合并效应量与样本量较小的研究删除之前的合并效应量相比,结果基本一致,说明此次Meta分析的结果比较稳定。结论男性骨密度的降低与冠状动脉粥样硬化之间没有显著的相关性。
[Abstract]:Objective to explore the relationship between changes in bone mineral density and coronary atherosclerosis in men from the perspective of evidence-based medicine. The China Biomedical Literature Database (CBMN), the Weip Information Resources system, the China Journal Full-text Database (CNKII), the Wanfang Database, and so on, have been used to retrieve the relevant documents published so far, and to extract the data from the documents that meet the inclusion criteria. Review Manager 5.3 Meta analysis software was used to analyze the extracted data. Results the study included 5 articles, including 325 patients with osteopenia and osteoporosis. Meta-analysis of 259 patients in the control group showed that the results of heterogeneity test among the five studies were: I ~ (2 +) ~ (2 +) ~ (2) (10. 56) P ~ (0.03), indicating that there was heterogeneity in each study, so the random effect model was used to analyze the heterogeneity. The combined effect was 1.79 / 95CI = 0.79 / 4.03P0.16.The heterogeneity test results showed that the heterogeneity was 24.64 / 0.20, which indicated that the heterogeneity between the two studies was small and acceptable. Therefore, a fixed effect model was used to analyze the heterogeneity. The combined effect was 1.2295 CI = 0.766 / 1.96 / P0. 41. The result of the combined effect was basically consistent with that before the deletion of the sample, and the result was similar to that before the deletion of the sample, and the result was similar to that before the deletion of the sample, and the result was similar to that before the deletion of the sample. Conclusion there is no significant correlation between the decrease of bone mineral density and coronary atherosclerosis in men.
【作者单位】：北京大学首钢医院骨科;
【分类号】：R543.3;R580

【相似文献】