叶酸干预H型高血压患者血浆同型半胱氨酸及动脉硬化的疗效

发布时间：2018-03-12 18:52

本文选题：H型高血压　切入点：叶酸　出处：《实用医学杂志》2017年16期 　论文类型：期刊论文

【摘要】：目的探讨叶酸干预治疗对H型高血压患者血浆同型半胱氨酸(Hcy)代谢变化及脉搏波传导速度(PWV)的影响。方法收集2014年3-12月就诊的H型高血压患者,用随机数字表法随机分为治疗组和对照组,均给予常规长效降压药物治疗,治疗组同时给予口服叶酸0.8 mg/d,对照组给予安慰剂治疗,每日1次,两组疗程均为12个月,观察血浆Hcy及PWV水平变化。结果共入选432例H型高血压患者,全为汉族,年龄(61.7±13.6)岁,男∶女=1.3∶1,合并疾病最多的为冠心病和2型糖尿病。两组给予治疗时间12个月,随访时间6~10个月,平均8个月,治疗后两组血浆Hcy(Z=-7.63,P=0.000)及PWV(Z=-3.16,P=0.002)水平差异有统计学意义。结论叶酸干预治疗可以明显使H型高血压患者的血浆Hcy水平降低,减缓动脉粥样硬化进程,降低心血管病危险因素。
[Abstract]:Objective to investigate the effects of folic acid intervention on plasma homocysteine cysteine (HCH) metabolism and pulse wave conduction velocity (PWV) in patients with type H hypertension. The treatment group was randomly divided into treatment group and control group, both of which were treated with routine long-term antihypertensive drugs. The treatment group was given oral folic acid 0.8 mg / d at the same time, and the control group was treated with placebo once a day. The course of treatment in both groups was 12 months. Results the plasma levels of Hcy and PWV were observed in 432 patients with type H hypertension, aged 61.7 卤13.6 years old, male: female 1.3: 1. Coronary heart disease and type 2 diabetes mellitus were the most complicated diseases in both groups for 12 months. The follow-up time ranged from 6 to 10 months (mean 8 months). After treatment, there were significant differences between the two groups in plasma levels of Hcystatin (ZH) -7.63 (P0. 000) and PWV (ZG)-3.16 (P0. 002). Conclusion folic acid intervention can significantly decrease plasma Hcy level and slow down the progression of atherosclerosis in patients with H type hypertension. Reduce risk factors of cardiovascular disease.
【作者单位】：新疆生产建设兵团医院;
【基金】：兵团科技攻关与成果转化计划项目(编号:2015AD008)
【分类号】：R544.1

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