静注丙种球蛋白联合糖皮质激素治疗急性重症病毒性心肌炎的临床研究

发布时间：2018-03-12 19:29

本文选题：急性　切入点：重症　出处：《泰山医学院学报》2016年11期 　论文类型：期刊论文

【摘要】：目的研究应用静注丙种球蛋白联合糖皮质激素治疗急性重症病毒性心肌炎的效果。方法回顾研究自2005年1月至2016年5月治疗的急性重症病毒性心肌炎患者共69例,按照治疗方法分为两组。研究组为常规治疗基础上,应用了静注丙种球蛋白联合糖皮质激素治疗;对照组为常规治疗基础上,应用了静注糖皮质激素治疗,未应用静注丙种球蛋白治疗。比较两种方法对该病死亡率、治愈率的影响。结果研究组病死率为18.75%,治愈率为81.25%;应用超声心动图检查观察心功能变化,多数在2至5天基本恢复正常。对照组病死率为75.68%,治愈率为24.32%。对两组存活的11例患者进行随访1年至10年,超声心动图检查均正常。研究组与对照组不同治疗方法的效果比较有显著性差异(χ~2=22.25,P0.01)。结论在急性重症病毒性心肌炎的治疗中,在常规治疗的基础上,结合对症处理,应用糖皮质激素联合经静脉注射丙种球蛋白可明显地提高对该病的治愈率。
[Abstract]:Objective to study the efficacy of intravenous immunoglobulin combined with glucocorticoid in the treatment of acute severe viral myocarditis. Methods 69 patients with acute severe viral myocarditis treated from January 2005 to May 2016 were retrospectively studied. The study group was treated with intravenous injection of gamma globulin combined with glucocorticoid, while the control group was treated with glucocorticoid on the basis of routine therapy. No intravenous gamma globulin was used. The effects of the two methods on the mortality and cure rate of the disease were compared. Results the mortality of the study group was 18.75 and the cure rate was 81.25. The changes of cardiac function were observed by echocardiography. The mortality of the control group was 75.68 and the cure rate was 24.32. 11 patients in the two groups were followed up for 1 to 10 years. The results of different treatment methods in the study group and the control group were significantly different (蠂 ~ 2 / 2 ~ (22.25) P ~ (0.01)). Conclusion in the treatment of acute severe viral myocarditis, on the basis of routine treatment, combined with symptomatic treatment, there is a significant difference between the study group and the control group in the treatment of acute severe viral myocarditis. Glucocorticoid combined with intravenous injection of gamma globulin can significantly improve the cure rate of the disease.
【作者单位】：青岛大学医学院;泰山医学院附属泰山医院心内科;泰安市中医院心内科;泰安市人民医院心内二科;莱芜市中医院心内科;
【分类号】：R542.21

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