人参煎剂对阿霉素致心衰患者血清bax、bcl-2蛋白表达及心功能的影响

发布时间：2018-03-14 20:41

本文选题：心力衰竭　切入点：阿霉素　出处：《山东医药》2017年17期 　论文类型：期刊论文

【摘要】：目的探讨人参煎剂对阿霉素致心衰患者bax、bcl-2蛋白表达及心功能的影响。方法选取阿霉素致心衰患者100例,随机分为心衰组和人参煎剂组各50例,另取体检健康对照组50例。两组心衰患者在相应西药对症治疗的基础上,人参煎剂组以5~10 g人参按照常规制成人参水煎剂,每日1剂,早晚各50 mL,治疗1个月为1个疗程,共治疗2个疗程。治疗结束后,采用Western blotting法检测三组血清bax、bcl-2蛋白表达,采用无创血流动力学监测系统检测左心室收缩压(LVSP)、左心室舒张末期压(LVEDP)、左心室内压最大上升速率(+dp/dtmax)、左心室内压最大下降速率(-dp/dtmax),采用彩色多普勒超声诊断仪检测左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)、左室短轴缩短率(LVFS)、左心室射血分数(LVEF)。结果心衰组与健康对照组比较血清bax、bcl-2蛋白表达有统计学差异(P均0.05)。与心衰组比较,人参煎剂组血清bax、蛋白表达降低,bcl-2蛋白表达升高,血流动力学指标LVSP、LVEDP、+dp/dtmax、-dp/dtmax以及心功能指标LVEDD、LVESD、LVFS、LVEF均明显改善(P均0.05)。结论人参煎剂能够明显改善阿霉素致心衰患者的心脏功能,其机制可能与影响患者血清bax、bcl-2蛋白表达有关。
[Abstract]:Objective to investigate the effect of ginseng decoction on the expression of baxon-2 protein and cardiac function in patients with heart failure induced by doxorubicin. Methods 100 patients with heart failure induced by adriamycin were randomly divided into two groups: 50 patients in the heart failure group and 50 in the ginseng decoction group. On the basis of the corresponding western medicine for symptomatic treatment, the ginseng decoction group was made into ginseng water decoction with 5g 10 g ginseng, 1 dose daily, 50 mL in the morning and evening, for 1 month as a course of treatment. After two courses of treatment, Western blotting method was used to detect the expression of bcl-2 protein in serum of three groups. The left ventricular systolic pressure (LVSPN), left ventricular end-diastolic pressure (LVEDPN), left ventricular maximum rate of pressure rise (DP / dtmax1), left ventricular pressure maximum rate of fall (-dp / dtmaxn) were detected by non-invasive hemodynamic monitoring system. Left ventricular end-diastolic diameter (LVEDDN), left ventricular end-systolic diameter (LVESD), left ventricular shortening rate (LVFSN), left ventricular ejection fraction (LVVEFN), and left ventricular ejection fraction (LVVEF). Results there were significant differences in the expression of bcl-2 protein between heart failure group and healthy control group (P < 0.05). In ginseng decoction group, the expression of baxand protein decreased, the expression of bcl-2 protein increased, the indexes of hemodynamics, such as LVEDP, dp / dtmax-dprdtmax and LVEDDD-LVESD-LVFSS-LVEF, improved the cardiac function of patients with heart failure induced by doxorubicin. The mechanism may be related to the influence of the expression of baxon2-2 protein in serum of patients.
【作者单位】：连云港市第一人民医院;
【分类号】：R541.6

【相似文献】