参斛复方不同剂型对冠状动脉粥样硬化性心脏病的疗效评价

发布时间：2018-03-14 23:24

本文选题：参斛复方　切入点：冠心病　出处：《中国中西医结合杂志》2017年10期 　论文类型：期刊论文

【摘要】：目的观察参斛复方不同剂型治疗冠状动脉粥样硬化性心脏病的临床疗效。方法将230例冠状动脉粥样硬化性心脏病患者随机分为3组:基础治疗组30例,试验组100例和对照组100例。基础治疗组给予冠心病基础治疗,试验组予冠心病基础治疗+参斛复方中药破壁饮片(3.5 g/袋,每次1袋,每日2次,开水冲服)治疗,对照组给予冠心病基础治疗+参斛复方合剂(每次50 m L,每日2次),各组均持续治疗6个月。检测各组患者治疗前后高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、总胆固醇(TG)、同型半胱氨酸(Hcy)、超敏C反应蛋白(hs-CRP)、血栓素(TXA2)及前列环素(PGI2)水平。结果治疗过程中脱落32例,最终完成198例。与本组治疗前比较,治疗后各组HDL、LDL、TG、Hcy及hs-CRP水平差异均无统计学意义(P0.05),对照组和试验组TXA2水平及TXA2/PGI2比值均降低(P0.05);与基础治疗组同期比较,治疗后对照组及试验组TXA2水平及TXA2/PGI2比值亦降低(P0.05)。结论参斛复方不同剂型在抗血小板聚集及改善微循环具有一定作用。
[Abstract]:Objective To observe the clinical efficacy of different dosage of Shenhu compound for the treatment of coronary atherosclerotic heart disease. Methods 230 cases of patients with coronary heart disease were randomly divided into 3 groups: 30 cases in the treatment group, 100 cases of test group and 100 cases in the control group. The treatment group was given basic treatment based crown heart disease, the test group received the basis of coronary heart disease compound Chinese medicine treatment + Shenhu broken pieces (3.5 g/ bag, 1 bag each time, 2 times daily, boiling water) treatment, the control group was given routine treatment plus coronary heart disease of Shenhu compound (L 50 m each time, 2 times daily), treatment groups were continued for 6 months. Before and after treatment in patients with high density detection lipoprotein (HDL), low density lipoprotein (LDL), total cholesterol (TG), homocysteine (Hcy), high sensitive C reactive protein (hs-CRP), thromboxane (TXA2) and prostacyclin (PGI2) level. The results of 32 cases treated off process, completed in 198 cases. The treatment group Before treatment, after treatment of HDL, LDL, TG, Hcy and hs-CRP level differences were not statistically significant (P0.05), the control group and the experimental group TXA2 level and TXA2/PGI2 ratio were decreased (P0.05); compared with the basic treatment group, control group and experimental group after treatment, TXA2 level and TXA2/PGI2 ratio were decreased (P0.05). Conclusion: Dendrobium Compound with different formulations in platelet aggregation and improve microcirculation has a certain role.

【作者单位】：广州中医药大学附属中山医院综合科;
【基金】：广东省中医药管理局资助项目(No.20132112)
【分类号】：R541.4

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