急性病毒性心肌炎心脏磁共振心肌首过灌注及与cTnT的相关性

发布时间：2018-03-16 02:30

本文选题：磁共振成像　切入点：心肌炎　出处：《临床心血管病杂志》2017年06期 　论文类型：期刊论文

【摘要】：目的:应用心脏磁共振心肌首过灌注技术(CMR-MPI)对急性病毒性心肌炎(AVM)进行定量分析,并获得灌注曲线下面积比与肌钙蛋白(cTn)T的关系。方法:纳入31例AVM患者(AVM组)与20例健康志愿者(对照组)。两组行3.0T心脏磁共振扫描,测定CMR-MPI灌注参数(曲线下面积比、达峰时间及相对峰值信号)和cTnT浓度。采用Spearman等级相关对CMR-MPI曲线下面积和血清cTnT浓度进行统计分析。结果:曲线下面积比:灌注正常区、减低区及缺损区分别为(52.80±3.05)%、(37.64±4.87)%、(26.23±2.29)%,P0.05;相对峰值信号强度分别为(44.91±3.16)%、(33.96±4.98)%、(29.94±3.75)%,P0.05;达峰时间分别为(34.22±4.89)s、(37.85±7.51)s、(38.24±6.06)s,P0.05。AVM组与对照组血清cTnT浓度分别为(0.578±1.127)ng/ml、(0.011±0.006)ng/ml,P0.05。Spearman等级相关分析AVM组CMR-MPI曲线下面积比与血清cTnT浓度的关系,rs=-0.557,P0.05。结论:CMR-MPI可定量评估AVM心肌缺血程度,AVM患者血清cTnT浓度与CMR-MPI曲线下面积比呈负相关,提示AVM心肌微循环障碍和心肌缺血可能是造成或加重心肌细胞损伤及cTnT释放的原因之一。
[Abstract]:Objective: to study the quantitative analysis of acute viral myocarditis (AVM) by cardiac magnetic resonance myocardial first-pass perfusion (CMR-MPI). The relationship between area ratio under perfusion curve and cardiac troponin C TnTntr T was obtained. Methods: 31 patients with AVM and 20 healthy volunteers (control group) and 20 healthy volunteers (control group) underwent 3. 0T cardiac magnetic resonance scan to measure the perfusion parameters of CMR-MPI (area ratio under the curve). Peak time and relative peak signal) and cTnT concentration. The area under CMR-MPI curve and serum cTnT concentration were statistically analyzed by Spearman grade correlation. Results: area ratio under curve: perfusion normal area, The relative peak signal intensity was 44.91 卤3.16 卤33.96 卤4.98 卤29.94 卤3.75P0.05, respectively, and the peak time was 34.22 卤4.89 ~ 37.85 卤6.06 卤6.06 卤6.06 卤6.06 卤6.06 卤0.05, respectively. The relative peak signal intensity was 0.578 卤1.127 ngml / ml 0.011 卤0.006 ngml / ml 0.011 卤0.006 ngml / ml 0.011 卤0.006 ngml / ml 0.011 卤0.006 ngml / ml 0.011 卤0.006 ng / ml / ml respectively. The relationship between the area under the CMR-MPI curve and the serum cTnT concentration in the AVM group was sr-0.755 P0.055.The results showed that the correlation between the area area and the serum cTnT concentration in the VM group was 0.578 卤1.127ngml / ml 0.011 卤0.006ngml / ml 0.011 卤0.006ngml / ml 0.011 卤0.006ngml / ml 0.011 卤0.006ngml / ml respectively. Conclusion the serum cTnT concentration and area ratio under the CMR-MPI curve can be negatively correlated with the serum cTnT concentration in AVM patients with myocardial ischemia. The results suggest that myocardial microcirculation disturbance and myocardial ischemia in AVM may be one of the causes of myocardial cell injury and cTnT release.
【作者单位】：昆明医科大学第二附属医院放射科;
【基金】：国家自然科学基金项目(No:81260213) 云南省教育厅科学研究重点项目(No:2014Z057) 云南省中青年学术技术带头人培养项目(No:2015HB068)
【分类号】：R445.2;R542.21

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