Siglec家族与动脉粥样硬化相关性免疫细胞关系的研究进展

发布时间：2018-03-19 22:23

本文选题：唾液酸结合性免疫球蛋白样凝集素　切入点：动脉粥样硬化　出处：《中国动脉硬化杂志》2017年07期 　论文类型：期刊论文

【摘要】：动脉粥样硬化(As)是一种慢性炎症性血管疾病,各类免疫细胞的活性在其形成过程中均具有重要的作用。研究证实唾液酸结合性免疫球蛋白样凝集素(Siglec)家族与多种炎症免疫细胞的活性调节关系密切,如Siglec-1,5和7与单核/巨噬细胞活性显著相关,Siglec-2,10参与B淋巴细胞活性调节,Siglec-5,9和14能够调控中性粒细胞活性等,提示Siglec家族可能通过调节免疫细胞活性参与As形成的过程。尽管目前尚缺乏全面的直接证据,但已证实Siglec-1与As病变的形成显著相关,且抑制其表达能够显著减轻病变的程度。为从糖生物学的角度审视As形成中炎症免疫因素的作用机制,并探索防治As的可能新靶点,本文拟对Siglec家族与As相关性免疫细胞关系的研究进展作一综述。
[Abstract]:Atherosclerosis is a chronic inflammatory vascular disease. The activity of all kinds of immune cells plays an important role in the formation of sialic acid binding immunoglobulin like agglutinin (sig) family, which is closely related to the activity regulation of various inflammatory immune cells. For example, Siglec-1P5 and Siglec-7 have a significant correlation with monocyte / macrophage activity. Siglec-2C10 is involved in the regulation of B lymphocyte activity. Siglec-5N9 and 14 can regulate neutrophil activity, and so on. It is suggested that Siglec family may participate in the process of as formation by regulating the activity of immune cells. Although there is no comprehensive direct evidence, it has been proved that Siglec-1 is significantly related to the formation of as lesions. In order to examine the mechanism of inflammatory immune factors in the formation of as from the point of view of glucose biology, and to explore the possible new target of prevention and treatment of as, the inhibition of its expression can significantly reduce the degree of pathological changes. This article reviews the research progress of the relationship between Siglec family and as-related immune cells.
【作者单位】：中国人民解放军第三军医大学药学系药物研究所;
【基金】：国家自然科学基金面上项目(81673427) 重庆市基础科学与前沿技术研究重点项目(cstc2015jcyj BX0093)
【分类号】：R543.5

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