同型半胱氨酸及视黄醇结合蛋白检测在冠心病诊断中的应用

发布时间：2018-03-20 16:24

本文选题：同型半胱氨酸　切入点：视黄醇结合蛋白　出处：《中国老年学杂志》2017年10期 　论文类型：期刊论文

【摘要】：目的探讨冠心病(CHD)患者血清中同型半胱氨酸(Hcy)及视黄醇结合蛋白(RBP)的浓度,探讨其联合检测对CHD的诊疗的作用。方法在河南省中医院心病科住院怀疑为CHD并行冠状动脉造影的患者共358例,其中293例经冠脉造影确诊为CHD,65例为非CHD设为对照组。根据CHD的临床特点分为急性心肌梗死组75例、不稳定型心绞痛组123例、稳定型心绞痛组95例;检测各组患者的血清Hcy及RBP浓度,分析其在CHD不同阶段中的意义。结果急性心肌梗死组、不稳定型心绞痛组、稳定型心绞痛组与对照组的血清甘油三酯(TG)及总胆固醇(TC)水平无统计学差异(P0.05),急性心肌梗死组血清Hcy、RBP水平高于对照组;不稳定型心绞痛组血清Hcy、RBP水平高于对照组;稳定型心绞痛组血清Hcy、RBP水平与对照组基本一个水平(P0.05)。结论血清Hcy及RBP的水平与CHD的严重程度呈正相关。
[Abstract]:Objective to investigate the serum levels of homocysteine cysteine (HcyA) and retinol binding protein (RBP) in patients with coronary heart disease (CHD). To explore the role of combined detection in the diagnosis and treatment of CHD methods 358 patients with suspected CHD and coronary angiography were hospitalized in Department of Heart Disease of Henan traditional Chinese Medicine Hospital. According to the clinical characteristics of CHD, the patients were divided into acute myocardial infarction group (75 cases), unstable angina group (123 cases) and stable angina group (95 cases). Serum Hcy and RBP levels were measured and their significance in different stages of CHD were analyzed. Results Acute myocardial infarction group, unstable angina pectoris group, acute myocardial infarction group, unstable angina pectoris group, acute myocardial infarction group, unstable angina pectoris group. There was no significant difference in serum triglyceride (TG) and total cholesterol (TCC) levels between stable angina pectoris group and control group (P 0.05), but the serum Hcyn RBP level in acute myocardial infarction group was higher than that in control group, and that in unstable angina pectoris group was higher than that in control group. Conclusion the serum levels of Hcy and RBP are positively correlated with the severity of CHD in patients with stable angina pectoris.
【作者单位】：河南省中医院检验科;河南中医药大学;
【基金】：国家高技术研究发展计划“863”计划(No.2014AA22304)
【分类号】：R446.1;R541.4

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