血清弹力蛋白水平与冠状动脉粥样硬化性心脏病的相关性研究

发布时间：2018-03-21 15:32

  本文选题：弹力蛋白　切入点：动脉粥样硬化　出处：《浙江大学》2015年硕士论文　论文类型：学位论文

【摘要】：目的 对比非冠状动脉粥样硬化性心脏病患者与冠状动脉粥样硬化性心脏病(冠心病)患者,以及不同类型的冠心病患者(稳定型心绞痛、不稳定型心绞痛与急性心肌梗死)中血清弹力蛋白的水平,分析血清弹力蛋白水平与冠状动脉粥样硬化性心脏病的相关性。 方法 连续选取在浙江大学附属第二医院心内科住院行冠状动脉造影的患者共253例,其中经冠状动脉造影明确诊断非冠心病患者96例,冠心病患者157例。收集所有入选患者的基线临床资料包括性别、年龄、糖尿病、高血压病、吸烟情况、体重指数等。入院后第二天清晨至少空腹8小时后抽取肘静脉血检测常规生化指标包括：空腹血糖、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)等,并留取血清标本冻存于-80℃待集中检测。用ELISA试剂盒测定样本的血清弹力蛋白水平。各组间进行单因素分析,将P0.05的变量纳入回归模型,多元线性回归分析弹力蛋白水平与性别、年龄等变量的关系。 结果 与非冠心病组比较,冠心病患者组年龄、性别、高密度脂蛋白、血清弹力蛋白均有统计学意义(P0.05),但两组在体重指数、空腹血糖、总胆固醇、甘油三酯、低密度脂蛋白、吸烟、高血压、糖尿病等均无统计学差异(P0.05)。各亚组患者与非冠心病患者临床基本资料的差异主要体现在年龄、体重指数以及性别(P0.05)；而在空腹血糖、总胆固醇、甘油三酯、HDL、LDL、吸烟、高血压、糖尿病均无明显显著性差异(P0.05)。而所有入组患者的血清弹力蛋白含量与甘油三酯浓度、性别以及吸烟情况相关。将与冠心病在统计学上有显著性差异的变量以及与血清弹力蛋白表达相关的变量应用逐步选择法进行多元线性回归,发现血清弹力蛋白浓度在同性别的冠心病患者中浓度明显偏高(P0.05),而在冠心病不同阶段并未发现显著差异。 结论 血清弹力蛋白水平在冠心病患者较非冠心病患者显著升高,但其与冠心病的类型无相关性。
[Abstract]:Purpose. Comparison was made between patients with non-coronary atherosclerotic heart disease and patients with coronary atherosclerotic heart disease (coronary heart disease) and patients with different types of coronary heart disease (stable angina pectoris). The levels of serum elastin in unstable angina pectoris and acute myocardial infarction (AMI) and the correlation between serum elastin levels and coronary atherosclerotic heart disease (CHD) were analyzed. Method. A total of 253 consecutive patients were selected for coronary angiography in the Department of Cardiology, affiliated to the second affiliated Hospital of Zhejiang University, of which 96 were definitely diagnosed by coronary angiography as non-coronary heart disease patients. 157 patients with coronary heart disease. Baseline clinical data including gender, age, diabetes, hypertension, smoking were collected. Body mass index (BMI). The following morning, at least 8 hours after admission, blood samples from elbow veins were taken to detect routine biochemical parameters such as fasting blood glucose, total cholesterol TCU, triglyceride TGN, high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), and so on. The serum samples were frozen at -80 鈩，

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