老年心力衰竭合并细菌性肺炎患者血清氨基末端脑钠肽原、热休克蛋白、降钙素原水平的变化及意义

发布时间：2018-03-22 03:25

本文选题：心力衰竭　切入点：细菌性肺炎　出处：《中国老年学杂志》2017年15期 　论文类型：期刊论文

【摘要】：目的探讨老年心力衰竭合并细菌性肺炎患者血清氨基末端脑钠肽原(NT-pro BNP)、热休克蛋白(HSP)70和降钙素原(PCT)水平的变化及临床意义。方法分别选取老年心力衰竭患者(心力衰竭组)、老年心力衰竭合并细菌性肺炎患者(合并肺炎组)、老年健康志愿者(对照组)各100例。检测并对比各组血清NT-pro BNP、HSP70、PCT水平。所有患者均实施对症支持治疗,对比心力衰竭合并肺炎患者中不同心功能分级、死亡者和存活者血清NT-pro BNP、HSP70、PCT水平差异。结果合并肺炎组患者血清NT-pro BNP、HSP70、PCT水平均远高于心力衰竭组和对照组(P0.05),且心力衰竭组血清NT-pro BNP、HSP70、PCT水平均远高于对照组(P0.05);合并肺炎患者血清NT-pro BNP、HSP70、PCT水平均随心功能分级的增加而明显升高(P0.05),且死亡者血清NT-pro BNP、HSP70、PCT水平远高于存活者(P0.05)。结论在老年心力衰竭合并细菌性肺炎患者中血清NT-pro BNP、HSP70、PCT水平均异常升高,且可用来评估患者的心功能及预后。
[Abstract]:Objective to investigate the changes and clinical significance of serum amino-terminal brain natriuretic peptide (NT-pro BNPN), heat shock protein (HSPN) 70 and procalcitonin (PCT) in elderly patients with heart failure complicated with bacterial pneumonia. The serum levels of NT-pro BNPN HSP70 and PCT were measured and compared in 100 elderly patients with heart failure complicated with bacterial pneumonia, 100 elderly healthy volunteers (control group) and 100 elderly patients with heart failure complicated with bacterial pneumonia. All patients were treated with symptomatic support therapy. To compare the different cardiac function grades in patients with heart failure and pneumonia. Results the serum levels of NT-pro BNPP HSP70 and PCT in the patients with pneumonia were significantly higher than those in the heart failure group and the control group (P 0.05), and the serum NT-pro BNPN HSP70 NT-pro levels in the heart failure group were significantly higher than those in the control group (P 0.05), and in the patients with pneumonia the levels were significantly higher than those in the control group (P 0.05). The serum levels of NT-pro BNPG HSP70 + PCT were significantly increased with the increase of cardiac function grade, and the serum NT-pro BNPG HSP70 / PCT levels were significantly higher in the dead patients than in the survivors. Conclusion the serum NT-pro BNPN HSP70PCT levels in the elderly patients with heart failure and bacterial pneumonia are all increased abnormally. It can be used to evaluate cardiac function and prognosis of patients.
【作者单位】：郑州中医骨伤病医院检验科;
【分类号】：R446.1;R541.6;R563.1

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