血清正五聚蛋白3与风湿性心脏病的关系

发布时间：2018-03-22 03:33

本文选题：风湿性心脏病　切入点：正五聚蛋白　出处：《中国免疫学杂志》2017年12期 　论文类型：期刊论文

【摘要】：目的:探讨正五聚蛋白3(Pentraxin 3,PTX3)、超敏C反应蛋白(hypersensitive C-reactive protein,hs-CRP)与风湿性心脏病(RHD)的相关性及意义。方法:以同期40名正常健康人作对照,选取我院住院RHD患者76例(排除人工瓣膜置换术后的风心病患者),根据心脏彩色多普勒超声检查及心电图情况分为房颤心律组和窦性心律组,联合瓣膜病变组和单瓣膜病变组,其中房颤RHD组48例,窦性心律组风心患者28例,联合瓣膜病变组46例,单瓣膜病变组30例,采用免疫增强比浊法测定hs-CRP,通过酶联免疫吸附(ELISA)法检测PTX3含量。结果:(1)RHD组的血清hs-CRP和PTX3水平明显高于对照组(P0.01);(2)房颤RHD组的血清PTX3水平明显高于窦性RHD组(P0.01),但房颤RHD组的血清hs-CRP水平与窦性RHD组差异无统计学意义(P0.05);(3)联合瓣膜病变组的PTX3水平和hs-CRP水平均高于单瓣膜病变组(P0.05)。结论:PTX3及hs-CRP在RHD中持续存在,RHD瓣膜病变的严重性使hs-CRP及PTX3浓度升高。PTX3是RHD房颤发生的影响因素之一,PTX3在RHD炎症反应表现中稳定性更高。
[Abstract]:Objective: to investigate the correlation and significance between pentagglutinin (3(Pentraxin 3), hypersensitive C-reactive protein (hs-CRP) and rheumatic heart disease (RHD). 76 patients with rheumatic heart disease (rheumatic heart disease after valve replacement) in our hospital were selected and divided into atrial fibrillation group and sinus rhythm group, combined valvular lesion group and single valve disease group according to echocardiography and electrocardiogram. There were 48 patients with atrial fibrillation in RHD group, 28 patients with rheumatic heart in sinus rhythm group, 46 patients with combined valvular disease and 30 patients with single valve disease. Hs-CRP was determined by immunoenhancement turbidimetric assay and PTX3 was detected by Elisa. Results the serum hs-CRP and PTX3 levels in the group of RHD were significantly higher than those in the control group (P 0.01). The level of serum PTX3 in the RHD group with AF was significantly higher than that in the RHD group with sinus RHD, but the level of PTX3 in the Atrial fibrillation group was significantly higher than that in the control group (P 0.01). There was no significant difference in serum hs-CRP level between RHD group and sinus RHD group. (P 0.05) PTX3 level and hs-CRP level in combined valvular disease group were higher than that in single valve disease group. Conclusion the severity of hs-CRP and PTX3 in RHD makes hs-CRP. PTX3 is one of the influencing factors of RHD atrial fibrillation. PTX3 is more stable in the inflammatory response of RHD.
【作者单位】：泸州市合江县人民医院;
【基金】：泸州市卫生局科研课题(No.泸市卫发[2014]245号)
【分类号】：R541.2

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