急性高血压脑出血患者血浆CXCL12水平与脑水肿的相关性研究

发布时间：2018-03-22 09:29

  本文选题：急性高血压脑出血　切入点：CXCL　出处：《国际神经病学神经外科学杂志》2017年03期 　论文类型：期刊论文

【摘要】：目的探讨急性高血压脑出血患者血浆CXCL12水平的动态变化及其对预后的影响,以及血浆CXCL12水平与相对水肿体积的关系。方法选择急性高血压脑出血患者34例,于发病24小时内、第3天、第7天和第14天采用ELISA法检测血浆CXCL12水平,选择同期25例健康体检者作为对照组。根据mRS评分将脑出血患者分为预后良好组(mRS≤2分)和预后不良组(mRS2分)。于发病24小时内、第3天和第7天根据颅脑CT计算相对水肿体积。结果脑出血组24小时内血浆CXCL12水平(19.85±1.84)μg/L明显高于对照组(11.34±2.23)μg/L,P0.01。脑出血组血浆CXCL12水平在第3天时快速上升(22.56±1.56)μg/L,在第7天达高峰(23.38±1.53)μg/L,在第14天时下降(22.64±1.78)μg/L。预后良好组与整体的变化趋势一致,预后不良组血浆CXCL12水平在第14天时未见下降;两组血浆CXCL12水平在第7天时和第14天时比较差异均有统计学意义,P值分别为0.05和0.01。Pearson相关性分析显示第3天和第7天血浆CXCL12水平与相对水肿体积呈正相关,相关系数分别为(r=0.631,P0.01)和(r=0.435,P0.05)。结论血浆CXCL12水平在脑出血后明显升高,持续性CXCL12水平升高的患者预后较差。动态检测血浆CXCL12水平能够为脑水肿的评估和治疗提供依据。
[Abstract]:Objective to investigate the dynamic changes of plasma CXCL12 level and its influence on prognosis in patients with acute hypertensive intracerebral hemorrhage and the relationship between plasma CXCL12 level and relative edema volume. Methods 34 patients with acute hypertensive intracerebral hemorrhage were selected within 24 hours after onset. On day 3, day 7 and day 14, plasma CXCL12 levels were measured by ELISA assay. 25 healthy persons were selected as control group. According to mRS score, the patients with ICH were divided into two groups: good prognosis group (MRs 鈮，

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