补肾活髓颗粒联合西药治疗慢性再生障碍性贫血临床疗效的倾向指数研究

发布时间：2018-03-22 19:06

本文选题：慢性再生障碍性贫血　切入点：倾向指数　出处：《中医杂志》2017年01期 　论文类型：期刊论文

【摘要】：目的应用倾向指数法比较补肾活髓颗粒联合西药治疗与单纯西药治疗慢性再生障碍性贫血的临床疗效。方法选择慢性再生障碍性贫血患者236例,随机分为治疗组158例和对照组78例。对照组给予口服司坦唑醇片每次2~4 mg,每日3次;环孢菌素软胶囊每次75 mg,每日2次。治疗组在对照组治疗基础上给予补肾活髓颗粒,每日1剂,分两次口服。两组均治疗6个月。应用倾向指数匹配法对两组患者基线资料进行匹配,对匹配前后两组临床疗效和匹配后、治疗前后两组患者的血红蛋白(HGB)、白细胞(WBC)及血小板(PLT)水平进行比较。结果两组各有76例成功匹配。匹配前两组临床疗效比较:对照组基本治愈16例,缓解14例,明显进步18例,总有效率61.54%;治疗组分别为50例、36例、34例及75.95%,两组比较差异无统计学意义(χ~2=6.71,P=0.08)。匹配后两组临床疗效比较:对照组基本治愈16例,缓解14例,明显进步17例,总有效率61.84%;治疗组分别为12例、18例、17例及61.84%,两组比较差异无统计学意义(χ~2=1.07,P=0.78)。匹配后两组患者治疗后HGB、WBC及PLT较治疗前均明显升高(P0.01),治疗组治疗后HGB和PLT均明显高于对照组(P0.05)。结论补肾活髓颗粒联合西药治疗慢性再生障碍性贫血在改善HGB及PLT方面优于单纯西药。
[Abstract]:Objective to compare the clinical efficacy of Bushen Huoxue granule combined with western medicine in treating chronic aplastic anemia with propensity index. Methods 236 patients with chronic aplastic anemia were selected. 158 cases in the treatment group and 78 cases in the control group were randomly divided into two groups. The control group was given 4 mg of stazolol tablets 3 times a day and 75 mg of cyclosporin soft capsule twice a day. The treatment group was given Bushen Huoxue granule on the basis of the treatment in the control group. Two groups were treated for 6 months. The baseline data of the two groups were matched by propensity index matching method. Before and after treatment, the levels of HGB, WBC and PLT were compared between the two groups. Results 76 cases in each group were matched successfully. Comparison of clinical efficacy between the two groups before and after treatment: 16 cases were cured, 14 cases were relieved, and 18 cases were improved obviously in the control group. The total effective rate was 61.54 and the treatment group was 50 cases with 36 cases or 34 cases and 75.95%, respectively. There was no significant difference between the two groups (蠂 2, 6.71%, P < 0.08). After matching, 16 cases were basically cured, 14 cases were relieved, and 17 cases were improved obviously in the control group. The total effective rate was 61.84; in the treatment group, it was 12 cases, 18 cases, 17 cases, and 61.84, respectively. There was no significant difference between the two groups (蠂 ~ (2) 0.07). After matching, the HGB and PLT of the two groups were significantly higher than that of the pre-treatment group. The HGB and PLT of the treatment group were significantly higher than those of the control group. Conclusion the treatment of chronic aplastic anemia with Bushen Huoxue granule combined with western medicine is superior to that of western medicine in improving HGB and PLT.
【作者单位】：潍坊医学院;潍坊医学院附属医院;
【基金】：山东省自然科学基金(ZR2014AQ020) 山东省科技发展计划(2012YD19013) 山东省中医药科技发展计划(2013-244)
【分类号】：R556.5

【相似文献】