探讨中性粒细胞和淋巴细胞比值与经皮冠状动脉介入术后对比剂肾病的关系

发布时间：2018-03-22 20:08

  本文选题：炎症　切入点：血管成形术　出处：《中国循环杂志》2017年09期 　论文类型：期刊论文

【摘要】：目的:探讨中性粒细胞和淋巴细胞比值(NLR)与经皮冠状动脉介入治疗(PCI)后对比剂对肾功能损害的关系。方法:入选我院2015-05至2016-12期间行PCI的患者176例,入院24 h内采血检测白细胞计数、中性粒细胞计数、淋巴细胞计数、血肌酐(SCr)、尿素氮(BUN)、尿酸(UA)、胱抑素C(CysC)等指标,并计算NLR。按NLR水平用三分位分组法将患者分为三组:低值组(NLR1.60,n=58)、中值组(1.60≤NLR≤2.36,n=62)及高值组(NLR2.36,n=56)。分别在PCI后48 h和72 h复查SCr及CysC,用Pearson相关分析探讨相关性,采用Logistic多因素回归分析判定NLR是否是对比剂肾病(CIN)的危险因素。结果:低值组、中值组和高值组的SCr及CycC水平较基线水平升高的绝对值的差异有统计学意义(P均0.05)。Pearson相关分析显示,NLR与SCr及CysC升高均呈正相关(r分别为0.785、0.764,P均0.05),Logistic回归分析显示NLR是CIN的独立危险因素(OR=4.152,95%CI:1.145~4.106)。结论 :NLR与对比剂肾功能损伤呈正相关,是CIN的独立危险因素。
[Abstract]:Objective: to investigate the relationship between neutrophil / lymphocyte ratio (NLR) and renal function damage after percutaneous coronary intervention (PCI). WBC count, neutrophil count, lymphocyte count, serum creatinine (SCR), urea nitrogen bun (BUNA), uric acid (UAA), cystatin (cystatin) CysC were measured within 24 hours after admission. The patients were divided into three groups according to the level of NLR. The patients were divided into three groups according to the level of NLR: low value group, low value group, low value group, 1.60 鈮，

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