5-脂氧合酶、同型半胱氨酸与颈动脉粥样硬化稳定性的关系研究

发布时间：2018-03-23 10:55

本文选题：脂氧合酶　切入点：同型半胱氨酸　出处：《重庆医学》2017年34期

【摘要】：目的研究血清5-脂氧合酶(5-LO)、同型半胱氨酸(Hcy)与颈动脉粥样硬化(CAS)斑块稳定性的关系。方法收集云南省第三人民医院经颈动脉超声诊断为CAS的患者共176名,并根据颈动脉超声结果分为稳定斑块组及易损斑块组;另收集同期该院体检中心体检并经由颈动脉超声排除CAS的健康志愿者108名为对照组;检测各组5-LO、Hcy的血清水平,并进行比较探讨两者与CAS斑块稳定性的关系;通过Logistic回归分析探讨CAS的危险因素并通过绘制ROC曲线探讨5-LO、Hcy预测颈动脉粥样硬化斑块稳定性的意义。结果 5-LO、Hcy在易损斑块组均较稳定斑块组及对照组高,差异有统计学意义(P0.05);稳定斑块组Hcy水平较对照组高(P0.05),而5-LO水平与对照组比较差异无统计学意义(P0.05);Logistic回归分析发现5-LO、Hcy、糖尿病是CAS的危险因素(P0.05)。ROC曲线提示以232.89pg/mL水平为临界值,血清5-LO水平预测斑块稳定性的敏感性为84.4%,特异度为81.8%;以12.53μmol/L为临界值,血清Hcy水平预测斑块稳定性的敏感性为70.1%,特异度为66.7%。结论血清5-LO及Hcy是预测CAS斑块稳定性的危险因素;调节二者水平可能成为临床稳定CAS的潜在靶点。
[Abstract]:Objective to study the relationship between serum 5-lipoxygenase (5-LOX) and plaque stability in carotid atherosclerosis. Methods 176 patients with CAS diagnosed by transcarotid ultrasound in the third people's Hospital of Yunnan Province were collected. According to the results of carotid ultrasound, 108 healthy volunteers were divided into stable plaque group and vulnerable plaque group, 108 healthy volunteers who were examined by physical examination center and excluded from CAS by carotid ultrasound in the same period were collected as control group, and the serum levels of 5-LOHcy were measured in each group. The relationship between them and the stability of CAS plaque was compared. The risk factors of CAS were analyzed by Logistic regression analysis and the significance of 5-LOHcy in predicting the stability of carotid atherosclerotic plaques was studied by drawing ROC curve. Results the levels of 5-LOHcy in vulnerable plaque group were higher than those in stable plaque group and control group. The level of Hcy in stable plaque group was higher than that in control group (P 0.05), but there was no significant difference in 5-LO level between control group and control group. Logistic regression analysis showed that 5-LOA Hcy. diabetes was a risk factor of CAS. The curve of P0.05? ROC suggested that 232.89pg/mL level was the critical value. The sensitivity of serum 5-LO level to predicting plaque stability was 84.4, the specificity was 81.8, the critical value of serum Hcy was 12.53 渭 mol/L, the sensitivity of serum Hcy level to predicting plaque stability was 70.1 and the specificity was 66.7. Conclusion Serum 5-LO and Hcy are risk factors for predicting plaque stability of CAS. Regulation of both levels may be a potential target for clinically stable CAS.
【作者单位】：云南省第三人民医院神经内科;昆明医科大学第一附属医院老年神经内科;四川大学华西医院神经内科;
【基金】：云南省第三人民医院/大理学院昆明直属医院院内课题(YJ201204)
【分类号】：R543.4

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