冠心病患者血清前蛋白转化酶枯草溶菌素9与小而密低密度脂蛋白胆固醇的相关性研究

发布时间：2018-03-26 07:22

本文选题：冠心病　切入点：前蛋白转化酶枯草溶菌素　出处：《中国动脉硬化杂志》2017年04期

【摘要】：目的探讨冠心病患者血清前蛋白转化酶枯草溶菌素9(PCSK9)与小而密低密度脂蛋白胆固醇(sd LDLC)的关系。方法收集2014年3月至2014年12月在山西医科大学第一医院住院且行冠状动脉造影术确诊为冠心病的患者100例作为冠心病组,同期健康体检者67例作为对照组。Lipoprint脂蛋白分析仪检测LDLC颗粒大小、sd LDLC颗粒数及sd LDLC所占LDLC的百分比(简称sd LDLC百分比);酶联免疫吸附法测定血清PCSK9。结果冠心病组LDLC颗粒大小低于对照组(264.07±6.78比267.37±5.15,P0.01),sd LDLC颗粒数多于对照组(5.0±9.5比4.0±5.0,P0.05),sd LDLC百分比大于对照组(5.95%±10.50%比3.70%±5.85%,P0.01)。冠心病组血清PCSK9显著高于对照组(15.48μg/L比14.95μg/L,U=-2.74,P=0.006)。冠心病组血清PCSK9与sd LDLC百分比、LDLC呈正相关(r=0.212,P=0.034;r=0.202,P=0.032)。结论冠心病患者血清PCSK9与sd LDLC百分比呈正相关,抑制PCSK9可以预防冠心病。
[Abstract]:Objective to investigate the relationship between serum proprotein converting enzyme (PCSK9) and small and dense low density lipoprotein cholesterol (LDLC) in patients with coronary heart disease (CHD). Methods from March 2014 to December 2014, the patients were hospitalized and performed in the first Hospital of Shanxi Medical University. 100 cases of coronary artery disease diagnosed by coronary angiography were used as coronary heart disease group. In the same period, 67 healthy persons served as control group. Lipoprint lipoprotein analyzer was used to detect the size of LDLC particles and the percentage of SD LDLC in LDLC. Elisa was used to detect serum PCSK9. Results in coronary heart disease group, the number of SD LDLC particles and the percentage of SD LDLC in LDLC were determined by enzyme-linked immunosorbent assay (Elisa). The LDLC particle size was lower than that of the control group (264.07 卤6.78 vs 267.37 卤5.15 渭 g / L = 267.37 卤5.15 渭 g / L vs 5.0 卤9.5 vs 4.0 卤5.0 vs 4.0 卤5.0 vs 4.0 卤5.0) respectively. The percentage of serum PCSK9 in coronary heart disease group was significantly higher than that in control group (5.95% 卤10.50% vs 3.70% 卤5.70% 卤5.70% 卤5.70% vs 3.70% 卤5.70%, P 0.01). The serum PCSK9 in CHD group was significantly higher than that in control group (15.48 渭 g / L vs 14.95 渭 g / L vs 14.95 渭 g / L vs 2.74 渭 g / L vs 14.95 渭 g / L vs 2.74 渭 g / L, P 0.006). Conclusion there is a positive correlation between the percentage of serum PCSK9 and SD LDLC in patients with coronary heart disease. Inhibition of PCSK9 can prevent coronary heart disease.
【作者单位】：山西医科大学第一临床医学院心内科;山西医科大学第二临床医学院心内科山西省临床心血管药理实验室;
【分类号】：R541.4

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