老年阻塞性睡眠呼吸暂停低通气综合征与左心室舒张功能不全的关系

发布时间：2018-03-26 20:19

本文选题：阻塞性睡眠呼吸暂停低通气综合征　切入点：舒张功能　出处：《中国老年学杂志》2017年13期

【摘要】：目的探讨老年阻塞性睡眠呼吸暂停低通气综合征(OSAS)与左心室舒张功能的关系及可能的潜在机制。方法纳入OSAS患者及对照组各313例,采用心脏超声检测E/A比值、等容舒张时间(IVRT)及E峰减速时间(EDT)以反映左室舒张功能,采用免疫酶联吸附方法检测血清白细胞介素(IL)-33和可溶性ST2(s ST2)含量并分析上述左室舒张功能指标与这些含量的关系。结果 OSAS患者E/A比值、IVRT明显小于对照组,但无统计学差异(P0.05);EDT明显短于对照组(P0.05);血清IL-33与对照组无差异(P0.05),但s ST2明显升高(P0.05)。s ST2与E/A比值、IVRT及EDT均呈正相关(P0.05或P0.01)。结论 OSAS人群存在左心功能不全,可能与缺氧导致的s ST2升高、抑制IL-33活性有关。
[Abstract]:Objective to investigate the relationship between obstructive sleep apnea hypopnea syndrome (OSAS) and left ventricular diastolic function and its potential mechanism. Isovolumic diastolic time (IVRTT) and E-peak deceleration time (EDTT) were used to reflect left ventricular diastolic function. The serum levels of interleukin-loride-33 and soluble ST2(s ST2 were measured by immunosorbent assay, and the relationship between the above indexes of left ventricular diastolic function and these contents was analyzed. Results the E / A ratio of patients with OSAS was significantly lower than that of the control group. However, there was no significant difference in P0.05EDT between the control group and the control group (P 0.05), but there was no significant difference in serum IL-33 between the control group and the control group (P 0.05), but s ST2 was significantly higher than that in the control group (P 0.05). The ratio of ST2 to E / A was positively correlated with EDT (P 0.05 or P 0.01). Conclusion there is left ventricular dysfunction in the OSAS population. It may be related to the increase of s ST2 induced by hypoxia and the inhibition of IL-33 activity.
【作者单位】：河源市人民医院耳鼻咽喉科;河源市人民医院心血管内科;中山大学孙逸仙纪念医院;广东省心电生理与心律失常实验室;
【基金】：国家自然科学基金项目(81300071) 广东省自然科学基金项目(2014A030313049) 广东省医学科研基金项目(A2014229,A2015019,A2016270) 广州市科技计划项目(201510010048,201510010050)
【分类号】：R541;R766

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