阿替普酶静脉溶栓对急性心肌梗死患者心肌损伤标志物及心功能的影响

发布时间：2018-03-27 04:59

本文选题：急性心肌梗死　切入点：静脉溶栓　出处：《广东医学》2017年S1期

【摘要】：目的观察阿替普酶对急性心肌梗死患者心肌损伤标志物及心功能的影响。方法选择急性ST段抬高型心肌梗死患者92例为研究对象,根据入院时间先后顺序随机分为观察组和对照组各46例,对照组给予尿激酶静脉溶栓治疗,观察组使用阿替普酶治疗,比较两组心肌损伤标志物、心功能、再通率及心血管事件发生率。结果观察组血清N末端脑钠肽前体、肌酸激酶同工酶、心肌钙蛋白含量均明显低于对照组(t=11.408、14.933、10.816,P0.05);左室射血分数明显高于对照组,左心室舒张末直径明显低于对照组(t=5.690、3.421,P0.05);两组患者冠脉再通率、出血率、低血压、恶性心律失常、心源性死亡发生率均差异无统计学意义(X~2=0.080、0.155、0.713、2.190,P0.05)。结论阿替普酶静脉溶栓治疗有助于降低急性心肌梗死患者血清心肌损伤标志物表达水平,改善心功能,且安全有效。
[Abstract]:Objective to observe the effects of atropase on myocardial injury markers and cardiac function in patients with acute myocardial infarction. Methods 92 patients with acute St segment elevation myocardial infarction were selected as subjects. According to the order of admission time, the patients were randomly divided into the observation group (n = 46) and the control group (n = 46). The patients in the control group were treated with urokinase intravenous thrombolytic therapy, and the patients in the observation group were treated with atropine enzyme. Results the contents of serum N-terminal brain natriuretic peptide precursor, creatine kinase isoenzyme and cardiac troponin in the observation group were significantly lower than those in the control group, and the left ventricular ejection fraction was significantly higher than that in the control group. The left ventricular end-diastolic diameter was significantly lower than that of the control group (5.690 ~ 3.421) (P 0.05), and the coronary artery recanalization rate, bleeding rate, hypotension, malignant arrhythmia in both groups were significantly lower than those in the control group. There was no significant difference in the incidence of cardiac death. Conclusion intravenous thrombolytic therapy with atropine can reduce the expression level of serum myocardial injury markers and improve cardiac function in patients with acute myocardial infarction, and it is safe and effective.
【作者单位】：北京大学国际医院急诊科;
【分类号】：R542.22

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