亚低温治疗心脏骤停的Meta分析

发布时间：2018-03-31 02:04

本文选题：心搏骤停　切入点：低温治疗　出处：《中国老年学杂志》2017年17期

【摘要】：目的评估心脏骤停患者接受亚低温治疗较常温治疗是否降低死亡率和改善神经功能预后。方法网络检索Pubmed,EMBASE and Cochrane图书馆等相关数据库,检索2016年10月以前发表的英文随机对照临床试验(RCTs),比较心脏骤停患者接受亚低温治疗(MTH)与常温治疗患者死亡率和神经功能改善的终点指标。结果总共从1 735篇文章中最终筛选了10篇RCTs,MTH较对照常温组可显著减少患者的死亡率(RR=0.92;95%CI,0.86~0.99;P=0.03,I2=17%),然而对神经功能改善并无明显差异(RR=1.22;95%CI,0.98~1.53;P=0.08,I2=53%)。结论心脏骤停患者接受亚低温治疗在减少死亡率方面优于常温治疗,然而需要更多的大型RCTs阐明其在神经功能改善方面的保护作用。
[Abstract]:Objective to evaluate whether mild hypothermia therapy can reduce mortality and improve nerve function prognosis in patients with cardiac arrest. Methods relevant databases such as Pubmedmedus Embus and Cochrane library were searched online. Objective: to retrieve RCTsN published before October 2016 in a randomized controlled clinical trial to compare the mortality and neurological improvement in patients with cardiac arrest treated with mild hypothermia (MTH) and normothermia. Results A total of 1,735 articles were published in this paper. In the chapter, 10 RCTs MTH were selected, which could significantly reduce the mortality rate of patients compared with the normal temperature group. Conclusion the mortality rate of patients with cardiac arrest treated with mild hypothermia is better than that of normothermic therapy. However, there is no significant difference in the improvement of neurologic function between the two groups. Conclusion the patients with cardiac arrest received mild hypothermia therapy is superior to normal temperature therapy in reducing mortality, but there is no significant difference in the improvement of neurologic function of RCTsN MTH. Conclusion the patients with cardiac arrest received mild hypothermia therapy is superior to normal temperature therapy in reducing the mortality of the patients with cardiac arrest, but there is no significant difference in the improvement of neurologic function. However, more large RCTs are needed to elucidate its protective role in improving neurological function.
【作者单位】：郑州人民医院;
【分类号】：R541.78

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