多功能线粒体Epac1控制心肌细胞死亡

发布时间：2018-04-01 11:25

  本文选题：Epac　切入点：心肌细胞　出处：《中华高血压杂志》2017年01期

【摘要】：正虽然第二信使环磷酸腺苷(cyclic AMP,cAMP)在生理上对心脏是有益的,但当其调控失常时在很大程度上促进心脏疾病进展。目前的证据表明,cAMP是在线粒体内产生的。然而,线粒体cAMP信号通路及其在心脏病理生理中的作用尚未知。该研究探讨在缺血/再灌注(ischemia/reperfusion,I/R)损伤情况下,由cAMP 1直接激活的线粒体交换蛋白(mitochondrial exchange protein directly activated by cAMP 1,MitEpac1)的作用。研究发现,Epac1基因切除
[Abstract]:Although is the second messenger cyclic AMP (cyclic AMP, cAMP) of the heart is beneficial in physiology, but when the regulation of arrhythmia largely promote heart disease progression. Current evidence suggests that cAMP is produced in mitochondria. However, mitochondrial cAMP signaling pathway and its role in the pathophysiology of heart is still unknown. The study on ischemia / reperfusion injury (ischemia/reperfusion, I/R) cAMP 1 cases by direct activation of mitochondrial protein (mitochondrial exchange protein directly exchange activated by cAMP 1, MitEpac1). The study found that Epac1 gene excision

【分类号】：R54
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本文编号：1695376