血清HSP70和TNF-α表达水平对宁夏回汉族原发性高血压的影响

发布时间：2018-04-10 20:46

本文选题：原发性高血压 + 肿瘤坏死因子-α　；参考：《现代预防医学》2017年09期

【摘要】：目的探讨血清热应激蛋白70(HSP70)和肿瘤坏死因子α(TNF-α)表达水平与宁夏回汉民族原发性高血压(EH)发病的关系。方法按照纳入与排除标准,从2011年10月至2012年10月期间在宁夏医科大学附属医院和吴忠市人民医院进行健康检查以及在内分泌科住院的人群中,选择229例无血缘关系的原发性高血压患者为病例组,600例无血缘关系的健康人为对照组。结果 EH组血清HSP70表达水平明显高于对照组(P0.05)。调整性别、年龄和民族因素后,HSP70高水平人群EH的发病风险是低水平人群的2.163倍。HSP70表达水平与收缩压(SBP)呈正相关(P0.001),与舒张压(DBP)无相关性(P0.05),TNF-α表达水平与SBP、DBP均呈正相关(均P0.05)。回汉民族间血清TNF-α表达水平差异均有统计学意义(均P0.05)。不同TNF-α表达水平间SBP、DBP水平差异均有统计学意义(均P0.05)。结论血清HSP70表达水平与原发性高血压发病密切相关,随着HSP70表达水平的增高,EH的发病风险也明显增高;TNF-α表达水平可能是原发性高血压的危险因素,也可能与种族遗传有关。
[Abstract]:Objective to investigate the relationship between the expression of serum heat stress protein 70 (HSP70) and tumor necrosis factor 伪 (TNF- 伪) and the incidence of essential hypertension (EH) in Hui Han nationality in Ningxia.Methods according to the criteria of inclusion and exclusion, from October 2011 to October 2012, health examinations were conducted in affiliated hospitals of Ningxia Medical University and people's Hospital of Wuzhong City, as well as in the population hospitalized in the Endocrinology Department.Two hundred and twenty-nine unrelated patients with essential hypertension were selected as the control group (n = 600).Results the expression of serum HSP70 in EH group was significantly higher than that in control group (P 0.05).There were significant differences in serum TNF- 伪 expression between Hui and Han nationalities (P 0.05).There were significant differences in DBP between different TNF- 伪 expression levels (all P 0.05).Conclusion the level of serum HSP70 expression is closely related to the pathogenesis of essential hypertension. With the increase of HSP70 expression level, the risk of EH is also significantly increased. The expression of TNF- 伪 may be a risk factor of essential hypertension, and may also be related to ethnic inheritance.
【作者单位】：宁夏医科大学公共卫生与管理学院;宁夏医科大学总医院;
【基金】：国家自然科学基金(No.81160110)
【分类号】：R544.11

【相似文献】