基层医院临床药师指导华法林抗凝治疗非瓣膜病心房颤动与传统治疗的差异

发布时间：2018-04-15 10:03

  本文选题：基层医院 + 临床药师　； 参考：《中国医院药学杂志》2017年03期

【摘要】：目的:探讨基层医院临床药师指导华法林抗凝治疗非瓣膜病房颤与传统治疗的差异,为基层医院临床药师开展临床药学服务提供参考。方法:2010年1月-2014年12月,收治非瓣膜病心房颤动患者58例,随机数字表法分成临床药师指导华法林抗凝治疗组28例(指导组)和非临床药师指导华法林抗凝治疗组30例(传统组)。指导组由临床药师采用药学服务模式指导患者华法林抗凝治疗、INR自主监测与剂量调整;传统组由医师依据INR值调整用药剂量、交代药物用法用量和注意事项的临床常规方式进行华法林抗凝治疗;2组目标国际标准化值(INR)均为2.0~3.0(年龄≥75岁者为1.5~2.5),治疗开始后每间隔5 d在院监测一次INR值。2组患者开始华法林抗凝治疗的第12个月做一次随访调查。结果:2组患者达目标国际标准化值(INR)的比例有显著性差异(P0.05);自我监测与剂量调整能力、用药依从性和安全性方面的随访调查,结果有显著性差异(P0.05)。结论:临床药师采用药学服务模式指导华法林抗凝治疗非瓣膜病心房颤动患者的方法效果显著。
[Abstract]:Objective: to explore the difference between warfarin anticoagulant therapy and traditional treatment in primary hospital clinical pharmacists, and to provide reference for clinical pharmacists to carry out clinical pharmaceutical care.Methods: from January 2010 to December 2014, 58 patients with non-valvular atrial fibrillation were treated.The method of random number table was divided into 28 cases of warfarin anticoagulant therapy group guided by clinical pharmacists and 30 cases of warfarin anticoagulant therapy group (traditional group) guided by non-clinical pharmacists.The guiding group was guided by pharmacists to guide the patients with warfarin anticoagulant therapy with independent monitoring and dose adjustment, while in the traditional group, the dosage was adjusted by physicians according to the value of INR.The standard value of Warfarin anticoagulant therapy in the two groups was 2.0 / 3.0 (1.5 / 2.5 for those aged 鈮，

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