内皮型一氧化氮合酶基因第4内含子基因多态性与冠状动脉扩张症的关系

发布时间：2018-04-19 12:27

本文选题：冠状动脉扩张症 + 一氧化氮合酶　；参考：《中国动脉硬化杂志》2017年12期

【摘要】：目的探究内皮型一氧化氮合酶(e NOS)基因第4内含子基因多态性与冠状动脉扩张症(CAE)的关系。方法纳入71例住院患者,采用病例对照研究方法选择冠状动脉扩张组30例和冠状动脉正常组41例。收集患者年龄、性别、吸烟史、饮酒史等一般资料。采用聚合酶链反应(PCR)技术,分析比较两组患者一氧化氮合酶基因第4内含子基因多态性。结果冠状动脉扩张组患者病变累及单支冠状动脉最多,共14例(46.7%);累及2支、3支冠状动脉患者分别为8例(26.7%)、8例(26.7%)。病变累及右冠状动脉最多,占44.4%;累及前降支、回旋支分别占31.5%和24.1%。冠状动脉扩张组与冠状动脉正常组aa、ab、bb基因型分布频率分别为13.3%、33.3%、53.3%和4.9%、17.1%、78%(P0.05)。冠状动脉扩张组与冠状动脉正常组a等位基因分布频率为30%、13.4%(P0.05)。经Logistic回归分析显示,内皮型一氧化氮合酶基因第4内含子a等位基因是冠状动脉扩张症发生的独立危险因素(P0.05,OR=3.327,95%CI=1.083~10.226)。结论内皮型一氧化氮合酶基因第4内因子a等位基因可能是冠状动脉扩张症发病的独立危险因素。
[Abstract]:Objective to investigate the relationship between intron 4 polymorphism of endothelial nitric oxide synthase (Enos) gene and coronary artery dilatation (CAE).Methods 71 inpatients were enrolled and 30 patients in coronary artery dilatation group and 41 patients in normal coronary artery group were selected by case-control study.Collect age, sex, smoking history, alcohol history and other general data.The polymorphism of intron 4 of nitric oxide synthase gene was analyzed and compared by polymerase chain reaction (PCR).Results in the coronary artery dilatation group, the single coronary artery was most involved in 14 patients (46.7%), and 8 patients with 2 branches and 3 coronary arteries (8 cases) were involved in 26. 7% of the coronary artery.The lesions involved the right coronary artery mostly (44.4%), the anterior descending branch (31.5%) and the circumflex branch (24.1%).The genotype frequencies of aaaababanbb in the coronary artery dilatation group and the normal coronary artery group were 13.3% and 33.3%, respectively.The distribution frequency of a allele in the coronary artery dilatation group and the normal coronary artery group was 30 ~ 13.4% (P 0.05).Logistic regression analysis showed that intron 4 of endothelial nitric oxide synthase gene was an independent risk factor of coronary artery dilatation.Conclusion Endothelial nitric oxide synthase gene 4 internal factor a allele may be an independent risk factor for coronary artery dilatation.
【作者单位】：天津医科大学一中心临床学院;天津市第一中心医院心血管内科;
【基金】：天津市卫生和计划生育委员会科技基金(2015KZ023)
【分类号】：R543.3

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