锦州地区血脂正常中年冠心病的影响因素研究

发布时间：2018-04-20 01:16

  本文选题：血脂正常 + 冠心病　； 参考：《锦州医科大学》2017年硕士论文

【摘要】：目的1、调查中年冠心病患者的一般资料(年龄、性别、生活行为方式及血液学检查指标等)。2、探讨血脂正常中年冠心病患者的影响因素,为冠心病的防治提供参考依据。方法1、采用现况调查法对锦州医科大学附属第一、三医院心血管内科经冠状动脉造影检查确诊为冠心病的中年人(45-59岁)960例进行问卷调查。2、采用病例-对照的研究方法,收集锦州医科大学附属第一及第三医院心血管内科经冠状动脉造影检查的血脂正常中年人(45-59岁)338例病例,对照随机选择于体检中心检查的血脂正常中年人346例并进行问卷调查,采用非条件logistic回归模型对影响血脂正常冠心病的因素进行分析。结果血脂正常冠心病发生的危险因素有年龄(OR=1.057,95%CI=1.009~1.106)、吸烟(OR=1.788,95%CI=1.131~2.827)、收缩压(OR=1.021,95%CI=1.011~1.031)、低密度脂蛋白LDL(OR=20.947,95%CI=11.267~38.944);胆红素血脂综合指数(TC/(TBIL+HDL))(OR=504.500,95%CI=86.107~2955.852),男性(OR=1.555,95%CI=1.031~2.347);保护因素为高密度脂蛋白(OR=0.746,95%CI=0.483~0.950)。TC/(HDL+TBIL)的ROC曲线下面积(AUC)为0.671(95%CI:0.630~0.711),TC/(HDL+TBIL)预测中年血脂正常冠心病的界值为0.34,敏感度为50.3%,特异度为80.1%。结论年龄、吸烟、收缩压、LDL、TC/(TBIL+HDL)是影响锦州地区血脂正常中年冠心病发生的重要危险因素,而高密度脂蛋白是保护因素,中年男性比女性患病率高。血脂正常人群TC/(TBIL+HDL)值大于0.34,建议降血脂治疗。
[Abstract]:Objective: 1. To investigate the general data (age, sex, lifestyle and hematological index) of patients with coronary heart disease (CHD) in middle age, to explore the influencing factors of normal blood lipid in middle-aged patients with coronary heart disease, and to provide reference for the prevention and treatment of coronary heart disease (CHD). Methods 1. A questionnaire survey was conducted on 960 middle-aged patients aged 45-59 years who were diagnosed as coronary artery disease by coronary angiography in the Department of Cardiovascular Medicine of the first and third affiliated hospitals of Jinzhou Medical University. A case-control study was used. A total of 338 healthy middle-aged patients aged 45-59 years with normal blood lipids were collected from the Department of Cardiovascular Medicine of the first and third affiliated Hospital of Jinzhou Medical University. 346 normal middle-aged people with normal blood lipids were randomly selected in the physical examination center and investigated by questionnaire. Non-conditional logistic regression model was used to analyze the factors affecting normal blood lipid coronary heart disease. 缁撴灉琛，

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