25-羟维生素D及甲状旁腺素与高血压发病关系:剂量反应Meta分析

发布时间：2018-04-20 18:10

本文选题：-羟维生素D + 甲状旁腺素　；参考：《重庆医科大学学报》2017年05期

【摘要】：目的:采用剂量反应Meta分析分别对25-羟维生素D[25-hydroxyvitamin D,25(OH)D]水平、甲状旁腺素(parathyroid hormone,PTH)水平与高血压发病风险进行综合评价。方法:全面检索Pub Med、Embase、CBM、CNKI和VIP数据库,纳入25(OH)D、PTH与高血压发病风险的前瞻性研究,检索时限均为建库至2016年8月。采用剂量反应模型对25(OH)D、PTH与高血压发病风险进行拟合,采用Stata13.0进行Meta分析。结果:共纳入9项前瞻性研究,研究对象为西方人群,样本含量25 658人。线性剂量反应Meta分析结果显示,25(OH)D每增加25 nmol/L,高血压的发病风险下降7%(RR=0.93,95%CI=0.89~0.97,P=0.000);而PTH每增加15 pg/m L,高血压的发病风险增加6%(RR=1.06,95%CI=1.02~1.10,P=0.001)。结论:针对西方人群,随着25(OH)D水平的降低或PTH水平的升高,可能导致高血压发病风险的增加。这给亚洲人群高血压的预防提供了重要线索。
[Abstract]:Objective: to evaluate the risk of hypertension by dose-response Meta analysis on the levels of 25 hydroxyvitamin D (25-hydroxyvitamin D), parathyroid hormone (PTH) and parathyroid hormoney (PTH). Methods: the database of Pub Medbase Embase (Pub) and VIP were searched, and the prospective study of 25 OHH Pub and the risk of hypertension was carried out. The searching time was established until August 2016. The dose response model was used to fit the risk of hypertension and Stata13.0 was used to analyze the risk of hypertension. Results: a total of 9 prospective studies were conducted with a sample size of 25,658 people in the western population. Linear dose response (Meta) analysis showed that for every 25 mol / L increase of 25 渭 mol / L, the risk of hypertension decreased by 7%, and that for every 15 pg/m / L increase of PTH, the risk of hypertension was increased by 6% RRN 1.0695 CI 1.021.10 Pu 0.001. Conclusion: with the decrease of 25(OH)D level or the increase of PTH level, the risk of hypertension may increase in the western population. This provides important clues to the prevention of hypertension in Asian populations.
【作者单位】：第三军医大学军事预防医学院卫生统计学教研室;第三军医大学大坪医院野战外科研究所;
【基金】：国家自然科学基金面上资助项目(编号:81473068) 国家社会科学基金资助项目(编号:14BTJ019)
【分类号】：R544.1

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