内皮调节对小动脉管腔运动影响的模型分析

发布时间：2018-04-21 22:14

本文选题：剪切力 + 内皮调节　；参考：《力学学报》2017年01期

【摘要】：微循环是血液和组织之间发生物质交换的主要场所,它可以通过改变管径实现对血压、血流量的局部调节.血管内皮层对小动脉运动有重要的调节作用.本文基于连续介质假设,建立了内皮调节过程中主要活性物质在管壁中的扩散-反应动力学模型,并分析了非线性黏弹性血管的径向运动特性.利用该模型首先得到了内皮舒张因子一氧化氮(NO)、平滑肌细胞内钙离子(Ca~(2+))以及磷酸化肌球蛋白(actin-myosin complexes,AMC)在管壁内的的径向浓度分布;为分析内皮调节的动态过程,进一步对小动脉的被动舒张、血流量发生扰动时的管径响应分别进行了模拟.研究结果显示:当没有活性物质参与调节小动脉被动舒张时,管径无振荡发生;当血流量变化引起内皮调节时,内皮舒张因子NO浓度和管径均出现衰减振荡,振荡周期约60 s.分析认为内皮调节对壁面剪切力的反馈控制,可能是NO浓度和管径产生周期性振荡的原因.内皮调节过程呈现的频谱特征可以为血管内皮功能障碍的诊断提供帮助.
[Abstract]:Microcirculation is the main place of substance exchange between blood and tissue. It can regulate blood pressure and blood flow by changing the diameter of blood tube. Vascular endothelium plays an important role in the regulation of arteriole motility. Based on the continuum hypothesis, the diffusion-reaction kinetics model of the main active substances in the endothelial regulation process is established, and the radial motion characteristics of the nonlinear viscoelastic vessels are analyzed. Using this model, the radial concentration distribution of endothelium relaxation factor nitric oxide (no), intracellular calcium (Ca ~ (2 +)) and phosphorylated myosin complexes (AMCs) in the vascular wall were obtained in order to analyze the dynamic process of endothelial regulation. Furthermore, the passive relaxation of arterioles and the diameter response of the vessel when the blood flow was disturbed were simulated. The results showed that when no active substance was involved in regulating the passive relaxation of arterioles, there was no oscillation in the diameter of the vessel, and when the endothelium was regulated by the change of blood flow, both the concentration of no and the diameter of the endothelium were attenuated and oscillated, and the oscillation period was about 60 s. It is concluded that the feedback control of the wall shear force caused by the endothelial regulation may be the reason for the periodic oscillation of the no concentration and the diameter of the tube. The spectral characteristics of endothelial regulation may be helpful for the diagnosis of vascular endothelial dysfunction.
【作者单位】：大连理工大学能源与动力学院;
【基金】：国家自然科学基金(51576033) 大连市科技计划(2015F11GH092)资助项目
【分类号】：R543;R318.01

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