依折麦布辛伐他汀片对冠心病患者颈动脉粥样硬化干预作用的疗效观察

发布时间：2018-04-22 09:29

本文选题：依折麦布辛伐他汀片 + 冠心病　；参考：《吉林医学》2017年01期

【摘要】：目的:观察依折麦布辛伐他汀片对冠心病患者颈动脉粥样硬化干预作用的疗效。方法:选取确诊为冠心病同时存在不同程度颈动脉粥样硬化的患者110例,按随机数字表法分为观察组和对照组,观察组58例,给予依折麦布辛伐他汀片30 mg 1/晚,同时根据需要给予其他必要的正规抗血小板、降压等治疗。对照组52例,给予辛伐他汀片20 mg 1/晚,并根据病情需要予以适当的常规治疗。疗程6个月,观察治疗前后血清总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)及颈动脉内膜-中层厚度(IMT)、颈动脉内膜斑块面积及斑块积分的变化。结果:治疗后观察组与对照组患者总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)均明显降低,高密度脂蛋白胆固醇(HDL-C)明显升高,且观察组较对照组更明显,组间差异有统计学意义(P0.05);两组患者治疗后斑块面积、颈总动脉内膜-中层厚度(IMT)及斑块积分显著减少,且观察组变化较对照更加明显,差异有统计学意义(P0.05);两组均未出现黄疸、肝功能损害、横纹肌溶解等严重病例。结论:依折麦布辛伐他汀片较单独应用辛伐他汀片组在逆转颈动脉粥样硬化及调脂方面效果更加显著且安全性更高。
[Abstract]:Aim: to observe the effect of ezeimebuxinvastatin tablet on carotid atherosclerosis in patients with coronary heart disease. Methods: 110 cases of coronary heart disease with different degree of carotid atherosclerosis were randomly divided into two groups: observation group (n = 58) and control group (n = 58). At the same time according to the need to give other necessary regular antiplatelet, hypotension and other treatment. 52 cases in the control group were treated with simvastatin 20 mg / night. The changes of serum total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), carotid intima-media thickness (IMT), carotid plaque area and plaque score were observed before and after treatment for 6 months. Results: after treatment, total cholesterol (TCN), triglyceride (TGN), low density lipoprotein cholesterol (LDL-C) in the observation group and the control group were significantly decreased, and HDL-C was significantly increased in the observation group than in the control group, and was more obvious in the observation group than in the control group. After treatment, the plaque area, IMT and plaque score of the common carotid artery decreased significantly in the two groups, and the changes in the observation group were more obvious than those in the control group (P 0.05). No jaundice was found in the two groups. Liver function damage, rhabdomyolysis and other serious cases. Conclusion: Ezemebuxinvastatin tablet is more effective and safer in reversing carotid atherosclerosis and regulating blood lipid than simvastatin alone.
【作者单位】：新疆医科大学第五附属医院;
【基金】：新疆维吾尔自治区自然科学基金资助项目[项目编号:2012211C124]
【分类号】：R541.4;R543.4

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