阿托伐他汀联合苯磺酸左旋氨氯地平治疗老年高血压合并颈动脉斑块的临床观察

发布时间：2018-04-22 10:38

本文选题：老年高血压 + 苯磺酸左旋氨氯地平　；参考：《中国药房》2017年12期

【摘要】：目的:观察阿托伐他汀联合苯磺酸左旋氨氯地平治疗老年高血压合并颈动脉斑块的疗效和安全性。方法:160例老年高血压合并颈动脉斑块患者随机分为对照组(80例)和观察组(80例)。对照组患者口服阿托伐他汀片3.0 mg,每日1次+复方利血平片2片,每日3次;观察组患者口服阿托伐他汀片(用法用量同对照组)+苯磺酸左旋氨氯地平片2.5 mg,每日1次。两组均连续治疗8个月。观察两组患者的降压疗效,治疗前后血压、颈动脉内膜中层厚度(IMT)水平及不良反应发生情况。结果:观察组患者降压总有效率显著高于对照组,差异有统计学意义(P0.05)。治疗前,两组患者血压和IMT水平比较,差异均无统计学意义(P0.05)。治疗后,两组患者血压和IMT水平均显著低于同组治疗前,且观察组显著低于对照组,差异均有统计学意义(P0.05)。两组患者不良反应发生率比较,差异无统计学意义(P0.05)。结论:阿托伐他汀联合苯磺酸左旋氨氯地平治疗老年高血压合并颈动脉斑块降压疗效较好,可有效控制血压,改善颈动脉内膜水平,且不增加不良反应的发生。
[Abstract]:Aim: to observe the efficacy and safety of Atto vastatin combined with levamlodipine benzenesulfonate in the treatment of elderly hypertension with carotid artery plaque. Methods 160 elderly patients with hypertension and carotid plaque were randomly divided into control group (n = 80) and observation group (n = 80). The patients in the control group were given 3. 0 mg Atto vastatin tablets, 2 compound reserpine tablets once a day, 3 times a day, and 2. 5 mg of Levamlodipine benzenesulfonic acid tablets once a day in the observation group. Both groups were treated continuously for 8 months. The antihypertensive effect, blood pressure, carotid intima-media thickness (IMT) and adverse reactions were observed. Results: the total effective rate of lowering blood pressure in the observation group was significantly higher than that in the control group, and the difference was statistically significant (P 0.05). Before treatment, there was no significant difference in blood pressure and IMT levels between the two groups (P 0.05). After treatment, the blood pressure and IMT levels of the two groups were significantly lower than those of the same group before treatment, and the observation group was significantly lower than the control group, the difference was statistically significant (P 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P 0.05). Conclusion: Atto vastatin combined with levamlodipine benzenesulfonate is effective in the treatment of hypertension with carotid plaque, which can effectively control blood pressure, improve carotid intimal level, and do not increase the occurrence of adverse reactions.
【作者单位】：河南大学淮河医院神经内科;
【基金】：国家自然科学基金资助项目(No.81601123)
【分类号】：R544.1;R543.4

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