冠心病患者血浆脂联素水平变化及其与冠状动脉病变的关系

发布时间：2018-04-28 00:37

本文选题：冠状动脉粥样硬化性心脏病 + 脂联素　；参考：《山东医药》2017年12期

【摘要】：目的探讨冠状动脉粥样硬化性心脏病(简称冠心病)患者血浆脂联素水平变化及其与冠状动脉病变血管支数、狭窄程度的关系。方法选择因胸闷、胸痛入院行冠状动脉造影检查的中青年(60岁)患者120例,根据冠状动脉造影结果确诊为冠心病100例(冠心病组),其中单支血管病变45例、双支病变30例、多支病变25例,Gensini积分轻度狭窄12例、中度狭窄45例、重度狭窄33例、极重度狭窄10例;造影结果正常20例(对照组)。采用ELISA法检测两组血浆脂联素,分析冠心病组血浆脂联素水平与病变血管支数、狭窄程度的关系。结果冠心病组血浆脂联素水平为(14.83±5.23)mg/L,对照组为(22.67±9.84)mg/L,两组比较P0.05。单支、双支、多支冠状动脉病变冠心病患者血浆脂联素水平分别为(18.53±6.23)、(14.47±4.11)、(9.82±3.82)mg/L,组间比较P均0.05;Gensini评分轻度、中度、重度、极重度狭窄冠心病患者血浆脂联素水平分别为(16.53±5.32)、(12.88±3.55)、(9.32±3.21)、(5.46±2.08)mg/L,组间比较P均0.05。结论冠心病患者血浆脂联素水平降低。血浆脂联素水平变化可反映冠状动脉病变血管支数及狭窄程度。
[Abstract]:Objective to investigate the changes of plasma adiponectin levels in patients with coronary atherosclerotic heart disease (CHD) and their relationship with the number and degree of coronary artery stenosis. Methods A total of 120 patients, aged 60 years old with chest pain, who were admitted to hospital for coronary angiography, were selected. 100 patients were diagnosed as coronary heart disease according to the results of coronary angiography (coronary artery disease group: 45 patients with single vessel disease and 30 patients with double vessel disease). Gensini integral stenosis was found in 12 cases, moderate stenosis in 45 cases, severe stenosis in 33 cases, extremely severe stenosis in 10 cases, and normal results in 20 cases (control group). Plasma adiponectin was measured by ELISA method. The relationship between plasma adiponectin level and the number and degree of stenosis in coronary heart disease group was analyzed. Results the plasma adiponectin level was 14.83 卤5.23 mg / L in coronary heart disease group and 22.67 卤9.84 mg / L in control group (P 0.05). The plasma adiponectin levels in patients with coronary artery disease were 18.53 卤6.23 mgL and 9.82 卤3.82 mg / L, respectively. The plasma adiponectin levels in patients with coronary heart disease were 16.53 卤5.32 卤3.55mgL, respectively. Conclusion the plasma adiponectin level was decreased in patients with coronary heart disease. The change of plasma adiponectin level can reflect the number of coronary artery branches and the degree of stenosis.
【作者单位】：海南省人民医院;
【基金】：国家自然科学基金资助项目(81260043)
【分类号】：R541.4

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