芪苈强心胶囊联合辅酶Q10对老年高血压并心衰患者心肌营养素-1、丙二醛水平的影响

发布时间：2018-04-28 01:25

本文选题：心衰 + 芪苈强心胶囊　；参考：《中国老年学杂志》2017年09期

【摘要】：目的观察芪苈强心胶囊联和辅酶Q10长程服用对老年高血压并心衰患者心肌营养素(CT-1)、丙二醛(MDA)和心功能的影响。方法选择年龄≥65岁的高血压心衰患者94例,随机分为治疗组和对照组,对照组常规抗心衰治疗,治疗组常规抗心衰治疗加用芪苈强心胶囊和辅酶Q10服用12 w,测定CT-1、MDA、N末端B型利钠肽原(NT-pro BNP)、左心室射血分数(LVEF)和6 min步行试验(6MWT)。结果治疗12 w两组CT-1、MDA、NT-pro BNP水平均较治疗前显著下降(P0.05,P0.01),6MWT、LVEF均较治疗前显著增高(P0.05,P0.01)。12 w治疗组CT-1、MDA和NT-pro BNP水平较对照组继续显著降低(P0.05),6MWT、LVEF较对照组显著增高(P0.05,P0.01)。12 w治疗组地高辛、呋塞米用量较对照组明显减少(P0.01)。结论芪苈强心胶囊联合辅酶Q10长程应用通过降低老年高血压并心衰患者CT-1、MDA和NT-pro BNP水平,进一步改善心功能。
[Abstract]:Objective to observe the effects of Qiliqiangxin capsule combined with coenzyme Q10 on myocardial nutrients CT-1, malondialdehyde (MDA) and cardiac function in elderly patients with hypertension and heart failure. Methods 94 patients with hypertension and heart failure aged more than 65 years were randomly divided into treatment group and control group. The treatment group was treated with Qiliqiangxin capsule and coenzyme Q10 for 12 weeks. NT-pro BNPP, left ventricular ejection fraction (LVEF) and 6 min walking test were measured. Results at 12 weeks after treatment, the levels of CT-1MDA-NT-pro BNP in both groups were significantly decreased compared with those before treatment. The levels of CT-1T BNP and NT-pro BNP in the treatment group were significantly higher than those in the control group. The levels of CT-1O and NT-pro BNP in the treatment group were significantly higher than those in the control group, and the levels of NT-pro BNP in the treatment group were significantly lower than those in the control group, and the levels of NT-pro BNP in the treatment group were significantly higher than those in the control group. The dosage of furosemide was significantly lower than that of control group (P 0.01). Conclusion Qiliqiangxin capsule combined with coenzyme Q10 can further improve cardiac function by decreasing the levels of CT-1MDA and NT-pro BNP in elderly patients with hypertension and heart failure.
【作者单位】：新乡医学院第三附属医院心内科;新乡医学院基础医学院;新乡医学院第二附属医院;
【基金】：河南省教育厅科学技术研究重点项目(No.13A320857)
【分类号】：R541.6;R544.1

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