床边快速检测NGAL对急诊冠脉介入后造影剂所致急性肾损伤预测的多中心研究

发布时间：2018-04-28 01:58

本文选题：中性粒细胞明胶酶载脂蛋白 + 急性心肌梗死　；参考：《实用医学杂志》2017年04期

【摘要】：目的:探讨中性粒细胞明胶酶载脂蛋白(NGAL)对肾功能相对正常患者行急诊冠脉介入(PCI)后造影剂所致急性肾损伤(CI-AKI)的早期预测价值。方法:入选2014年12月至2015年8月因急性心梗于广东省人民医院、茂名市人民医院和东莞市人民医院行急诊PCI且肾功能相对正常[e GFR60 m L(min·1.73 m2)]患者73例。采用床边快速检测仪测定血NGAL。利用受试者工作曲线(ROC)评估NGAL对CI-AKI的预测价值。结果:5例(6.85%)患者发生CI-AKI,且其NGAL水平高于非CI-AKI组。ROC曲线显示,术前、术后4 h及8 h NGAL对CI-AKI有较高预测价值,曲线下面积分别为0.755、0.761、0.809。结论术前、术后4 h及8 h床边快速检测NGAL对行急诊PCI且肾功能相对正常患者发生CI-AKI有较高预测价值,今后可能成为诊断早期CI-AKI的快速手段。
[Abstract]:Aim: to investigate the early predictive value of neutrophil gelatinase apolipoprotein (NGALs) for acute renal injury induced by contrast agent after emergency coronary intervention (PCI) in patients with relatively normal renal function. Methods: from December 2014 to August 2015, 73 patients with acute myocardial infarction in Guangdong Provincial people's Hospital, Maoming people's Hospital and Dongguan people's Hospital received emergency PCI with relatively normal renal function [e GFR60 m L(min 1.73 m2]. The blood NGALs were measured by a fast bedside detector. The predictive value of NGAL to CI-AKI was evaluated by using the operating curve of subjects. Results the CI-AKI was found in 5 patients (6. 85%), and its NGAL level was higher than that in non CI-AKI group. NGAL had a high predictive value for CI-AKI 4 and 8 hours before and after operation, and the area under the curve was 0. 755 卤0. 761and 0. 809, respectively. Conclusion the rapid detection of NGAL at bedside at 4 h and 8 h postoperatively is of high predictive value for the occurrence of CI-AKI in patients with emergency PCI and normal renal function. It may be a rapid method for the diagnosis of early CI-AKI in the future.
【作者单位】：南方医科大学研究生学院;广东省人民医院广东省医学科学院广东省心血管病研究所南方医科大学;广东省人民医院广东省医学科学院广东省心血管病研究所心内科;广东省东莞市人民医院;广东省茂名市人民医院;
【基金】：2012年中国医师协会阳光心血管研究基金项目(编号:SCRFCMDA201216) 2014年广东省科技厅公益研究与能力建立项目(编号:2014A020212635)
【分类号】：R692;R542.22

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