前列地尔注射液联合阿魏酸哌嗪对老年高血压肾病的疗效及对Cys-C、CRP的影响

发布时间：2018-05-01 08:07

本文选题：前列地尔注射液 + 阿魏酸哌嗪　；参考：《中国老年学杂志》2017年21期

【摘要】：目的探讨前列地尔注射液联合阿魏酸哌嗪对老年高血压肾病的疗效及对胱抑素(Cys)-C、C反应蛋白(CRP)的影响。方法 116例老年高血压肾病按照不同治疗方法分为治疗组和对照组各58例。对照组应用前列地尔注射液治疗,治疗组应用前列地尔注射液联合阿魏酸哌嗪治疗。比较两组临床疗效、血压、24 h尿蛋白定量、尿素氮、血肌酐及Cys-C、CRP水平。结果治疗后,治疗组总有效率显著高于对照组(P0.05)。两组血压水平较治疗前显著下降,且治疗组收缩压(SBP)和舒张压(DBP)水平改善情况均优于对照组(P0.05)。两组24 h尿蛋白定量、尿素氮及血肌酐水平均较治疗前明显下降,且治疗组下降较对照组更显著(P0.05)。两组Cys-C、CRP水平与治疗前相比显著下降,且治疗组下降程度更显著(P0.05)。结论前列地尔注射液联合阿魏酸哌嗪治疗老年高血压肾病不仅可有效改善患者血压、24 h尿蛋白定量、尿素氮及血肌酐水平,还能有效降低患者Cys-C、CRP水平,其临床疗效显著。
[Abstract]:Objective to investigate the effect of Alprostadil Injection combined with piperazine ferulic acid on senile hypertensive nephropathy and the effect on cystatin (Cys) -C, C reactive protein (CRP). Methods 116 elderly patients with hypertension and kidney disease were divided into 58 cases in the treatment group and the control group according to different treatment methods. The control group should be treated with Alprostadil Injection, and the treatment group applied Prost The clinical efficacy of two groups, blood pressure, 24 h urine protein quantitative, urea nitrogen, serum creatinine and Cys-C, CRP levels were compared. The total effective rate of the treatment group was significantly higher than that of the control group (P0.05) after treatment. The blood pressure level in the two groups was significantly lower than that before the treatment, and the level of systolic pressure (SBP) and diastolic pressure (DBP) in the treatment group was improved. Two groups of 24 h urine protein quantitative, urea nitrogen and serum creatinine levels were significantly lower than before the treatment, and the treatment group decreased more significantly than the control group (P0.05). Two groups of Cys-C, CRP level compared with before treatment significantly decreased, and the treatment group was more significant (P0.05). Conclusion Alprostadil Injection combined with ferulic acid piperazine The treatment of senile hypertensive nephropathy can not only improve the blood pressure of the patients, 24 h urine protein, urea nitrogen and serum creatinine, but also effectively reduce the level of Cys-C and CRP. The clinical effect is significant.

【作者单位】：福建医科大学附属第二医院肾脏内科;
【基金】：福建省自然科学基金(No.2016Y0032)
【分类号】：R544.1;R692

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