时辰药理学结合动态血压优化厄贝沙坦服药时间的临床研究

发布时间：2018-05-01 07:35

本文选题：时辰药理学 + 动态血压　；参考：《中国医院药学杂志》2017年24期

【摘要】：目的:在时辰药理学原理指导下,把药物达峰时间与患者的24 h动态血压相结合,从而确定降压药的最佳服用时间,做到个体化给药。方法:将某院2015年1月-2016年6月住院和门诊收治的高血压患者共100例,随机分为干预组和对照组,各50例。干预组中患者根据其服药前动态血压仪测得的峰值前2 h服药,对照组按常规服药时间早餐后服药。在治疗8周后对2组患者血压控制情况进行比较分析,并记录所有与厄贝沙坦相关的不良反应。结果:治疗前2组患者平均血压之间无明显差异,经治疗后,在随访期内其血压水平均较治疗前有显著下降,治疗后干预组较对照组患者在24h平均收缩压、白天平均收缩压、全天收缩压大于140 mmHg的百分率、全天收缩压大于140 mmHg的时间百分率有明显差异(P0.05),但在24h平均舒张压、白天平均舒张压、夜间平均收缩压、夜间平均舒张压等方面无明显差异(P0.05)。结论:时辰药理学原理指导下结合降压药的药动学特点制定的给药时间能更平稳地降压,为合理、个体化地使用降压药提供依据。
[Abstract]:Objective: under the guidance of chronological pharmacology, the peak time of the drug was combined with the 24 h ambulatory blood pressure (ABBP) of the patients, so as to determine the best time of taking antihypertensive drugs and to make individual administration. Methods: from January 2015 to June 2016, 100 patients with hypertension were randomly divided into intervention group (n = 50) and control group (n = 50). The patients in the intervention group took medicine 2 hours before the peak measured by the ambulatory blood pressure meter before taking the medicine, while the control group took the medicine according to the routine time of taking medicine after breakfast. After 8 weeks of treatment, blood pressure control in both groups was compared and all adverse reactions associated with irbesartan were recorded. Results: there was no significant difference in the mean blood pressure between the two groups before treatment. After treatment, the blood pressure levels in the follow-up period were significantly lower than those before the treatment. The mean systolic blood pressure in the intervention group was higher than that in the control group in 24 hours and the mean systolic blood pressure in the day after treatment. The percentage of whole day systolic blood pressure greater than 140 mmHg and the percentage of whole day systolic blood pressure greater than 140 mmHg were significantly different (P 0.05), but there was no significant difference in 24 h mean diastolic blood pressure, daytime average diastolic blood pressure, night mean systolic blood pressure and night mean diastolic blood pressure. Conclusion: according to the pharmacokinetic characteristics of hypotensive drugs under the guidance of chronological pharmacology, the time of administration can decrease blood pressure more smoothly, which provides the basis for rational and individualized use of antihypertensive drugs.
【作者单位】：佛山市南海区人民医院药学科;佛山市南海区人民医院心血管内科;
【分类号】：R544.1

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