高血压相关炎症因子的研究进展

发布时间：2018-05-05 10:01

本文选题：高血压 + 炎症因子　；参考：《南昌大学》2017年硕士论文

【摘要】：高血压是中老年常见的心血管类疾病之一,也是诱发冠心病、脑卒中、心力衰竭以及终末期肾病等并发症的重要病因和危险因素,具有病程长、控制难、终身服药的特点,目前发病机制尚不明确。炎症因子是指与炎症的发生、发展和预后等过程密切相关的一类细胞因子,由免疫细胞(如单核-巨噬细胞、淋巴细胞等)和非免疫细胞(如血管内皮细胞等)所产生和分泌,包括CRP、TNF-α、白介素、细胞间粘附因子、一氧化氮合酶、基质金属蛋白酶等。炎症因子一般多为多肽、蛋白质或糖蛋白,通过其疫调节功能来调节细胞增殖和诱导细胞分化,并参与细胞生长、分化、修复和免疫等过程。近年来,国内外多项研究表明,在高血压前期人群中,血清炎症因子水平已经出现了一定的变化;高血压患者体内炎症因子水平明显升高,与正常人群存在显著性差别。这表明高血压属于一种低度炎症状态性疾病,炎症反应在高血压疾病的发生、发展等过程中可能扮演了重要的角色。为此,本文通过参阅国内外有关的文献报道,系统地概括了一些炎症因子的作用机制,综述了当前高血压与其相关炎症因子的相关关系以及最新的研究进展,以期为高血压的早期诊断、临床治疗以及改善患者长期预后等方面提供有效的参考依据。
[Abstract]:Hypertension is one of the common cardiovascular diseases in the middle and old age. It is also an important etiology and risk factor for the complications of coronary heart disease, stroke, heart failure and end-stage nephropathy. It has the characteristics of long course of disease, difficult to control, and life-long medication. At present, the pathogenesis is not clear. Inflammatory factors are a class of cytokines closely related to the occurrence, development and prognosis of inflammation. They are produced and secreted by immune cells (such as monocyte-macrophages, lymphocytes, etc.) and non-immune cells (such as vascular endothelial cells). These include CRP- TNF- 伪, interleukin, intercellular adhesion factor, nitric oxide synthase, matrix metalloproteinases and so on. Inflammatory factors are usually polypeptides, proteins or glycoproteins. They regulate cell proliferation and induce cell differentiation through its epidemic regulation function, and participate in the process of cell growth, differentiation, repair and immunity. In recent years, many studies at home and abroad have shown that the level of serum inflammatory factors has changed in the pre-hypertensive population, and the level of inflammatory factors in the patients with hypertension is significantly higher than that in the normal population. This indicates that hypertension is a low-grade inflammatory state disease, and inflammatory reaction may play an important role in the process of the occurrence and development of hypertension. Therefore, this paper systematically summarizes the mechanism of some inflammatory factors, summarizes the relationship between hypertension and its related inflammatory factors and the latest research progress by referring to the relevant literature reports at home and abroad. In order to provide effective reference for early diagnosis, clinical treatment and improvement of long-term prognosis of hypertension.
【学位授予单位】：南昌大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R544.1

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