补肾通络颗粒对高血压病早期肾损害血清胱抑素C的影响研究

发布时间：2018-05-08 10:27

本文选题：早期肾损害 + 高血压病　；参考：《山东中医药大学》2015年硕士论文

【摘要】：目的:本研究通过监测高血压病早期肾损害患者治疗前后血清胱抑素C的变化,观察补肾通络颗粒对高血压病早期肾损害患者血清胱抑素C的影响,并初步探讨其机制。方法:在山东省立医院中医科及心血管内科2013年5月至2014年06月的住院患者中收集符合纳入标准的高血压病早期肾损害患者60例,随机分为治疗组和对照组,两组均给予相同的基础治疗,如低盐低脂饮食,戒烟酒,适当参加体育锻炼等;若合并高脂血症或高尿酸血症等给予对症处理;所有患者均根据病情给予缬沙坦胶囊口服,治疗组加用补肾通络颗粒,8周为一个疗程。检测治疗前后血清胱抑素C的变化及尿微量白蛋白(mALb)、尿β2-微球蛋白(β2-MG)、血视黄醇结合蛋白(RBP)等指标及血压变化;同时检测血常规、肝肾功等安全性指标及中医症状改善情况,并进行统计学处理。结果:两组均能降低血清胱抑素C,且治疗组优于对照组(P0.01);两组均能降低尿微量白蛋白、尿β2微球蛋白及血视黄醇结合蛋白,且治疗组优于对照组;治疗组降压总有效率96.67%,明显优于对照组(86.67%)(P0.05);治疗组中医症状综合疗效有效率为86.67%,明显优于对照组(53.33%)(P0.01),治疗组降低中医症状积分优于对照组(P0.01)。结论:补肾通络颗粒配合西医治疗高血压病早期肾损害患者能明显降低胱抑素C的水平,有效改善肾功能,可以改善患者中医临床症状、控制血压,显示出中西医结合治疗本病的存在一定的优势。
[Abstract]:Objective: to observe the effect of Bushen Tongluo granule on serum cystatin C in patients with early renal injury of hypertension before and after treatment, and to explore its mechanism. Methods: from May 2013 to June 2014, 60 patients with early renal damage of hypertension were collected from Department of traditional Chinese Medicine and Department of Cardiovascular Medicine, Shandong Provincial Hospital, and randomly divided into treatment group and control group. Both groups were given the same basic treatment, such as low-salt and low-fat diet, alcohol and tobacco withdrawal, proper participation in physical exercise, and symptomatic treatment if combined with hyperlipidemia or hyperuricemia. All patients were given valsartan capsules orally according to their condition. The treatment group was treated with Bushen Tongluo granule for 8 weeks as a course of treatment. Before and after treatment, the changes of serum cystatin C, urinary microalbuminuria, urinary 尾 2-microglobulin (尾 2-MGG), serum retinol binding protein (RBP) and blood pressure were detected, and the safety indexes such as blood routine examination, liver and kidney function, and the improvement of TCM symptoms were also detected. Statistical analysis was carried out. Results: the serum cystatin C was decreased in both groups, and the treatment group was superior to the control group (P 0.01), and both groups could reduce the urinary microalbumin, 尾 2 microglobulin and serum retinol binding protein, and the treatment group was superior to the control group. The total effective rate of lowering blood pressure in the treatment group was 96.67, which was obviously superior to that in the control group (86.67), and the comprehensive effective rate of TCM symptom in the treatment group was 86.67, which was obviously better than that in the control group (53.33). The treatment group was superior to the control group in reducing the score of TCM symptoms (P 0.01). Conclusion: Bushen Tongluo granule combined with western medicine can significantly reduce the level of cystatin C, improve renal function, improve the clinical symptoms of traditional Chinese medicine and control blood pressure. It shows that there are some advantages in the treatment of this disease by the combination of traditional Chinese and western medicine.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R544.14

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